The Role of Mononuclear Phagocytes as Accessory Cells in Lymphocyte Responses
For some time it has been known that certain immunologic functions of lymphocytes require the addition of mononuclear phagocytes in order to be operative. Historically, Mosier and Coppleson (1968) initially described a need for adherent cells in animal in vitro primary immune responses. As the supportive role of adherent cells in immune responses became apparent, efforts were made to identify the lineage of this accessory cell. The evidence to date indicates that although a number of cells can function as accessory cells, mononuclear phagocytes are the predominant accessory cell type operational in many current immunologic assay systems. Mononuclear phagocytes have been employed as accessory cells in both their blood monocyte and tissue macrophage forms; both animal and human research systems abound.
KeywordsMononuclear Phagocyte Accessory Cell Null Cell Primary Immune Response Natural Killer Cell Function
Unable to display preview. Download preview PDF.
- Chang, Y., and Yao, C., 1979, Investigation of the human macrophage. I. Collection and in vitro cultivation, Eur. J. Immunol. 9:577.Google Scholar
- Fagnani, R., Zicht, R. R., Bonnard, G. D., and Herberman, R. B., 1983, Accessory cell functions of the human leukemic cell line K562, submitted for publication (personal communication).Google Scholar
- Kurland, J. I., 1978, Regulatory interactions of the macrophage in B lymphocyte proliferation, J. Reticuloendothelial Soc. 24:19.Google Scholar
- Oppenheim, J. J., Mizel, S. B., and Meltzer, M. S., 1979, Comparison of lymphocyte and mononuclear phagocyte derived mitogenic “amplification” factors, in: Biology of the Lymphokines (S. Cohen, E. Pick, and J. J. Oppenheim, eds.), Academic Press, New York.Google Scholar
- Stevenson, H. C., Katz, P., Wright, D. G., Contreras, T. J., Jemionek, J. F., Hartwig, V. M., Flor, W. J., and Fauci, A. S., 1981, Human blood monocytes: Characterization of negatively selected human monocytes and their suspension cell culture derivatives, Scand. J. Immunol. 14:243.PubMedCrossRefGoogle Scholar
- Van Wauwe, J., and Goosens, J., 1981, Mitogenic actions of OKT3 on human peripheral blood lymphocytes: Effects of monocytes and serum components, J. Immunopharmacol. 44:865.Google Scholar