Immunology pp 13-26 | Cite as

The Role of Macrophages in Nonspecific Processes

  • Michael E. Miller


Interest in the role of macrophages as “nonspecific” mediators of host defense has been heightened in recent years. The importance of macrophages in the inflammatory response is not a new concept, having been first suggested by Metchnikoff (1893) who noted from his observations of tubercle bacilli that “the polynuclear cells engulf the tubercle bacilli readily, but perish after a short time and then with the microbes they contain, are eaten up by various mononuclear phagocytes which may be classed together under the term of macrophages. These latter cells have a much greater power of resistance and in some cases are even capable of destroying the tubercle bacilli.”


Bactericidal Activity Cord Blood Chronic Granulomatous Disease Mononuclear Phagocyte Human Neonate 
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Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • Michael E. Miller
    • 1
  1. 1.Department of PediatricsUniversity of California at Davis School of MedicineDavisUSA

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