Immunology pp 289-301 | Cite as

Role of Prostaglandins in Macrophage Cell Function

  • Steven L. Kunkel
  • Stephen W. Chensue
  • Joseph C. Fantone
  • Peter A. Ward


Since their discovery in the 1930s as potent autacoids, and their subsequent isolation and characterization in the 1960s as derivatives of arachidonic acid, prostaglandins have been the topic of many symposia and the basis for exhaustive research. These ubiquitous fatty acid derivatives have proven to be extremely powerful chemicals synthesized by nearly every cell in the human body, except the erythrocyte. Their synthesis and release have shown to be dependent upon a wide variety of cell membrane perturbations ranging from slight mechanical or chemical disturbances to the binding of compounds to specific receptors. Increasing evidence supports the theory that prostaglandins of all types are “made on demand” and not stored, since the amount of prostaglandins released from specific cells, in response to an appropriate stimulus, is greater than the total prostaglandin content of the cells prior to stimulation (Horton, 1979).


Phorbol Myristate Acetate Mononuclear Phagocyte Phorbol Myristate Acetate Mouse Peritoneal Macrophage Granulomatous Response 


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Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • Steven L. Kunkel
    • 1
  • Stephen W. Chensue
    • 1
  • Joseph C. Fantone
    • 1
  • Peter A. Ward
    • 1
  1. 1.Department of PathologyUniversity of Michigan Medical SchoolAnn ArborUSA

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