For years relegated to a position of second-class citizenship as a lowly scavenger devoid of the sophisticated recognition and control mechanisms of lymphocytes, the macrophage has now come into its own. The publication of this volume on the immunology of the reticuloendothelial system (RES) represents the acquisition of a long-deserved position of status among the cellular elite. We now appreciate that in immune reactions the macrophage takes advantage of its ability to interact with antigens nonspecifically, but then imposes profound restrictions upon future specific antigen-dependent reactions. Not only does the macrophage play a key role in initiating an immune reaction, but subsequent modulation of the host response is affected by macrophages. Additionally, macrophages form a major bulwark of host defense mechanisms through their ability to affect inflammation, directly kill microbes, and augment cytolytic lymphocytes. The protean manifestations of macrophage functions in the immune responses are considered in this volume. The purpose of this chapter is to provide a brief overview of the macrophage role in immunity. Detailed and exhaustive treatments of specific topics will be found in the other chapters of this volume. The major areas touched upon here are general characteristics of the monocyte-macrophage systems, lymphocyte interactions, macrophage killing, secretion, ontogeny, and human disorders of the macrophages.
KeywordsChronic Granulomatous Disease Monocytic Leukemia Brucella Abortus Reticulum Cell Sarcoma Immature Thymocyte
Unable to display preview. Download preview PDF.
- Biozzi, G., Stiffel, C., Mouton, D., Bouthillier, Y., and Decreusefond, C., 1968, Artificial selection for antibody production in mice, Ann. Inst. Pasteur (Paris) 115:965.Google Scholar
- Blaese, R. M., 1975, Macrophages and the development of immunocompetence, in: The Phagocytic Cell in Host Resistance (J. A. Bellanti and D. H. Dayton, eds.), pp. 309–320, Raven Press, New York.Google Scholar
- Blaese, R. M., 1976, Macrophage function in the development of immunocompetence and in immunodeficiency, J. Reticuloendothelial Soc. 20:67.Google Scholar
- Cianciolo, G., Hunter, J., Silva, J., Haskill, J. S., and Snyderman, R., 1981, Inhibitors of monocyte responses to chemotaxins are present in human cancerous effusions and react with monoclonal antibodies to the P15(3) structural protein of retroviruses, J. Clin. Invest. 68:831.PubMedCrossRefGoogle Scholar
- DiLuzio, N. R., 1979, Lysozyme, glucan-activated macrophages and neoplasia, J. Reticuloendothelial Soc. 26:67.Google Scholar
- Katz, H. R., LeBlanc, P. A., and Russell, S. W., 1981, An antigenic determinant shared by mononuclear phagocytes and mast cells, as defined by monoclonal antibody, J. Reticuloendothelial Soc. 30:349.Google Scholar
- Kurland, J. I., 1978, Regulatory interaction of the macrophage in B lymphocyte proliferation, J. Reticuloendothelial Soc. 24:19.Google Scholar
- Reikvam, A., Grammeltvedt, R., and Hoiby, E., 1975, Activated mouse macrophages: Morphology, lysosomal biochemistry, and microbiocidal properties of in vivo and in vitro activated cells, Acta Pathol. Microbiol. Scand. 83:129.Google Scholar
- Territo, M., and Cline, M., 1976, Macrophages and their disorders in man, in: Immunobiology of the Macrophage (D. S. Nelson, ed.), p. 594, Academic Press, New York.Google Scholar
- Wagner, H., and Rollinghoff, M., 1978, T-T cell interactions during in vitro cytotoxic allograft responses. I. Soluble products from activated Ly 1 + T cells trigger autonomously antigen primed Ly 23 + T cells to cell proliferation and cytolytic activity, J. Exp. Med. 148: 1523.PubMedCrossRefGoogle Scholar