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Sodium-Hydrogen Antiport, Cell Function and Susceptibility to Diabetic Nephropathy

  • Roberto Trevisan
  • Giancarlo Viberti

Abstract

The annual incidence of diabetic nephropathy rises rapidly over the first 15–20 years of diabetes, but declines sharply afterward for longer disease duration [1]. This pattern of risk indicates that only a subset of diabetic patients are susceptible to renal damage and, indeed, clinical renal disease cumulatively develops in approximately 30% of insulin-dependent diabetic (IDDM) patients [2] and between 15 and 60% of non-insulin-dependent diabetic (NIDDM) patients, depending on their ethnic origin[3]. Familiar clustering of diabetic nephropathy has been shown both in IDDM [4] and NIDDM patients [5]. These findings are consistent with the possibility that genetic factors may explain the liability to or protection from renal disease of diabetic patients.

Keywords

Diabetic Patient Diabetic Nephropathy Essential Hypertension Skin Fibroblast Intermediate Phenotype 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media Dordrecht 1998

Authors and Affiliations

  • Roberto Trevisan
    • 1
    • 2
  • Giancarlo Viberti
    • 1
    • 2
  1. 1.Department of Clinical and Experimental MedicineUniversity of PaduaPaduaItaly
  2. 2.Division of MedicineGuy’s and St Thomas’s Medical and Dental SchoolLondonUK

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