The Concept of Birth Weight and Renal Disease
Much attention has been focused on the lack of nutrition in the early environment of human beings, in order to explain the development of disease in adult life [1,2]. Nutrition in an inadequately nourished foetus may be reserved for the developing brain, at the expense of other less important organs such as the pancreas and the kidney. These organs may then in later life suffer from diseases because they have been deprived of nutrition at a crucial stage in their development. In the kidney, for instance, the embryological development is very tightly controlled . In vitro studies have shown that manipulation of the matrix of glomerular morphogenesis may generate less developed nephrons , and in vivo studies have shown that protein restriction in pregnant rats results in new-born rats with fewer and a smaller number of glomeruli [5,6].
KeywordsBirth Weight NIDDM Patient Placental Weight Current Body Mass Index Glomerular Number
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