Insulin and Blood Pressure

  • Rijk O. B. Gans
  • Ab J. M. Donker


Insulin resistance and compensatory hyperinsulinaemia are common features of obesity and non-insulin-dependent diabetes mellitus, conditions that are frequently complicated by hypertension [1,2]. The documentation of insulin resistance, i.e. a defective non-oxidative glucose disposal, and hyperinsulinaemia in untreated patients with essential hypertension and a normal glucose tolerance [3] has been the incentive for a vast number of studies assessing hyperinsulinaemia as the potential link between hypertension, obesity and diabetes mellitus. Apart from its role in glucose metabolism, insulin has several effects that might interfere with blood pressure homeostasis (table 29-1). In this chapter we will focus on the effect of insulin on the kidney and its (acute) cardiovascular effects, and conclude with alternative hypotheses to explain the association between hyperinsulinaemia, insulin resistance and hypertension.


Insulin Resistance Essential Hypertension Insulin Infusion Sodium Retention Skeletal Muscle Blood Flow 


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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Rijk O. B. Gans
    • 1
  • Ab J. M. Donker
    • 1
  1. 1.Afdeling Inwendige Geneeskunde Kliniek, Academisch ZiekenhuisVrije UniversiteitAmsterdamThe Netherlands

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