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Non-Glycaemic Intervention in Diabetic Nephropathy: The Role of Dietary Protein Intake

  • James D. Walker

Abstract

By the time clinical diabetic nephropathy is diagnosed by persistent proteinuria and a declining glomerular filtration rate (GFR), treatment options to preserve renal function are limited. Improving glycaemic control at this stage of the disease process is difficult and has little influence on the rate of decline of the GFR [1–3] whereas treatment of a raised blood pressure (BP) is more efficacious [4–8]. Dietary protein restriction has long been known to influence renal function [9] and numerous studies have tested the effect of dietary protein restriction in various renal diseases [10]. Additionally in animal models of chronic renal failure dietary protein restriction lessens proteinuria, mesangial expansion and glomerulosclerosis and preserves GFR [11–14]. This chapter discusses the influence of dietary protein on renal function and examines the effects of the therapeutic manoeuvre of restricting dietary protein in diabetic nephropathy.

Keywords

Glomerular Filtration Rate Diabetic Nephropathy Dietary Protein Vegetable Protein Renal Plasma Flow 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • James D. Walker

There are no affiliations available

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