The Course of Incipient and Overt Diabetic Nephropathy: The Perspective of More Optimal Insulin Treatment
The long-term objective of insulin treatment of insulin dependent diabetes mellitus (IDDM) is prevention of late complications. Through the years it has been a widely accepted hypothesis that development of such microvascular complications should be, at least in part, due to the lack of good glycaemic control. This hypothesis has been unduely hard to prove but results from a number of small scaled intervention studies and the result of the larger scaled American Diabetes Control and Complication Trial (DCCT) has now decisively documented, that development and progression of diabetic complications is closely associated with poor glycaemic control. The design and outcome of a number of these studies will be presented and discussed in this chapter as will the practical consequences of this newly gained knowledge.
KeywordsFiltration Albumin Neuropathy Proteinuria Uremia
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