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Insulin and Blood Pressure

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The Kidney and Hypertension in Diabetes Mellitus

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Abstract

Insulin resistance and compensatory hyperinsulinaemia are common features of obesity and non-insulin-dependent diabetes mellitus, conditions that are frequently complicated by hypertension [1,2]. The documentation of insulin resistance, i.e. a defective non-oxidative glucose disposal, and hyperinsulinaemia in untreated patients with essential hypertension and a normal glucose tolerance [3] has been the incentive for a vast number of studies assessing hyperinsulinaemia as the potential link between hypertension, obesity and diabetes mellitus. Apart from its role in glucose metabolism, insulin has several effects that might interfere with blood pressure homeostasis (table 25–1). In this chapter we will focus on the effect of insulin on the kidney and its (acute) cardiovascular effects, and conclude with alternative hypotheses to explain the association between hyperinsulinaemia, insulin resistance and hypertension.

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Authors
  1. Rijk O. B. Gans
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  2. A. B. J. M. Donker
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Editor information

Editors and Affiliations

  1. Medical Department M (Diabetes & Endocrinology) Aarhus Kommunehospital, University Hospitals in Aarhus, Aarhus C, Denmark

    Carl Erik Mogensen

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© 1994 Springer Science+Business Media New York

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Gans, R.O.B., Donker, A.B.J.M. (1994). Insulin and Blood Pressure. In: Mogensen, C.E. (eds) The Kidney and Hypertension in Diabetes Mellitus. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-6746-9_25

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  • DOI: https://doi.org/10.1007/978-1-4757-6746-9_25

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-6748-3

  • Online ISBN: 978-1-4757-6746-9

  • eBook Packages: Springer Book Archive

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