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Insulin and Blood Pressure

  • Rijk O. B. Gans
  • A. B. J. M. Donker

Abstract

Insulin resistance and compensatory hyperinsulinaemia are common features of obesity and non-insulin-dependent diabetes mellitus, conditions that are frequently complicated by hypertension [1,2]. The documentation of insulin resistance, i.e. a defective non-oxidative glucose disposal, and hyperinsulinaemia in untreated patients with essential hypertension and a normal glucose tolerance [3] has been the incentive for a vast number of studies assessing hyperinsulinaemia as the potential link between hypertension, obesity and diabetes mellitus. Apart from its role in glucose metabolism, insulin has several effects that might interfere with blood pressure homeostasis (table 25–1). In this chapter we will focus on the effect of insulin on the kidney and its (acute) cardiovascular effects, and conclude with alternative hypotheses to explain the association between hyperinsulinaemia, insulin resistance and hypertension.

Keywords

Insulin Resistance Essential Hypertension Insulin Infusion Capillary Density Peripheral Vascular Resistance 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Rijk O. B. Gans
  • A. B. J. M. Donker

There are no affiliations available

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