Sodium-Hydrogen Antiport, Cell Function and Susceptibility to Diabetic Nephropathy

  • Roberto Trevisan
  • Giancarlo Viberti


The annual incidence of diabetic nephropathy rises rapidly over the first 15–20 years of diabetes, but declines sharply afterward for longer disease duration [1]. This pattern of risk indicates that only a subset of diabetic patients are susceptible to renal damage and, indeed, clinical renal disease cumulatively develops in approximately 30% of Type 1 (insulin-dependent) diabetic patients [2] and between 25 and 60% of Type 2 (non-insulin-dependent) diabetic patients, depending on their ethnic origin [3]. Familial clustering of diabetic nephropathy has been shown both in insulin-dependent [4] and non-insulin-dependent diabetic patients [5]. These findings are consistent with the possibility that genetic factors may explain the liability to or protection from renal disease of diabetic patients.


Diabetic Patient Diabetic Nephropathy Raise Blood Pressure Culture Skin Fibroblast Extracellular Matrix Production 
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© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Roberto Trevisan
  • Giancarlo Viberti

There are no affiliations available

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