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Experimental Allergic Encephalomyelitis

  • Marian W. Kies

Abstract

The association between myelin basic protein (BP) and experimental allergic encephalomyelitis (EAE) has been long and intimate. A purified well-characterized antigen was essential for studies of pathogenesis, and the existence of BP was not even suspected until a search for the causative agent of EAE was undertaken.1–3 In spite of the considerable amount of data that has accumulated on the antigen and its role in pathogenesis, there are still many unanswered questions regarding the immunologic mechanisms involved in the induction and control of this experimental disease. The large quantity of literature precludes a complete review. Instead, I shall cover only a few of the recent developments in research on BP and EAE, which I hope will eventually provide answers for some of the unanswered questions.

Keywords

Myelin Basic Protein Suppressor Cell Lymph Node Cell Experimental Allergic Encephalomyelitis Peritoneal Exudate Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1985

Authors and Affiliations

  • Marian W. Kies
    • 1
  1. 1.Section on Myelin Chemistry, Laboratory of Cerebral MetabolismNational Institute of Mental HealthBethesdaUSA

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