A solution of 22.7 g (0.13 mole) of methyl 5-(chloromethyl)-2-furoate (see p. 29), b.p. 114–116° /3 mm, in 200 ml of dry benzene was prepared in a 500-ml three-necked round-bottomed flask fitted with mercury-sealed stirrer and reflux condenser protected by a calcium chloride tube, and it was stirred and cooled with ice water for two hours while 40 g (0.3 mole) of anhydrous aluminum chloride was added in small portions. When the vigorous reaction ceased, the mixture was heated in a water bath (temperature of bath 80–85°) for 4–5 hours (see Notes).
KeywordsAluminum Hydroxide Heterocyclic Compound Reflux Condenser Chloric Acid Zinc Chloride
- 1.A. L. Mndzhoian, V. G. Afrikian, and A. A. Dokhikian, Doklady Akad. Nauk Arm. SSR (Proc. Acad. Sci. Armenian SSR) 17, 164 (1953).Google Scholar