A solution of 174 g (about 1 mole) of methyl 5-(chloromethyl)-2-furoate (see Vol. 1 of this work, p. 29), b.p. 114–116°/3 mm, in 400 ml of methanol was prepared in a one-liter three-necked round-bottomed flask fitted with mercury-sealed stirrer, dropping funnel, and thermometer. The solution was stirred while a solution of 100 g (about 1.5 moles) of technical potassium cyanide in 200 ml of water was added rapidly; the temperature of the mixture then rose to 25–30°. The mixture was then heated in a water bath to 30–35°, and the temperature was kept in this range while stirring was continued for six hours.
KeywordsHeterocyclic Compound Anhydrous Sodium Sulfate Lithium Aluminum Aluminum Hydride Colorless Needle
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- O. Moldenhauer, G. Trautmann, W. Irion, R. Pfluger, H. Doser, D. Mastaglio, H. Marwitz, and R. Schulte, A. 580, 169 (1953).Google Scholar