Principles of Antibiotic Therapy
Antimicrobial agents are used to prevent infection, manage established infections, and treat presumptive infections. To correctly administer these compounds, clinicians must understand the indications, spectrum, pharmacodynamics, potential for drug-induced adverse reactions and drug-drug interactions, and relative cost (1). In the surgical intensive care unit (SICU), physicians must be aware of the unique pathogens and their antibiotic profiles, because patients in this setting are often seriously ill, immunosuppressed hosts who have undergone extensive surgical procedures and received numerous antibiotics.
KeywordsSurgical Intensive Care Unit Asymptomatic Bacteriuria Trough Serum Concentration Infection Control Practice Advisory Committee Hospital Infection Control Practice Advisory
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