Skip to main content

Ischemic Stroke

  • Chapter
  • 188 Accesses

Abstract

Ischemic stroke is becoming an increasingly important condition for intensivists to recognize and manage in order to minimize neurologic injury. It is a major public health issue because it is the third leading cause of death and the leading cause of adult disability. Devastating ischemic brain injury often strikes patients who are in the hospital for treatment of an unrelated medical or surgical condition. From 5% to 10% of acute strokes occur in the critical care and postoperative units and on hospital floors. Stroke complicating another illness is a cause of increased in-hospital stay, mortality, and long-term morbidity (1). Stroke in the intensive care unit (ICU) can be classified into three major categories (See Table 1) according to: 1) the presence of a variety of adverse events associated with increased stroke risk; 2) the presence of conditions that cause critical care illnesses as well as ischemic stroke; and 3) stroke as the primary reason for critical care admission, seen much more frequently in the post-thrombolysis era. Postoperative stroke, though rarely seen after general surgery (0.08 to 2.9% of cases), occurs more frequently after cardiac or vascular procedures and in patients with various cerebrovascular risk factors (2).

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   74.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Roach GW, Kanchuger M, Mangano CM, Newman M, Nussmeier N, Wolmar R, Aggarwal A, Marschall K, Graham SH, Ley C. Adverse cerebral outcomes after coronary bypass surgery. Multicenter Study of Perioperative Ischemia Research Group and the Ischemia Research and Education Foundation Investigators. N Engl J Med 1996; 335: 1857–63.

    Article  PubMed  CAS  Google Scholar 

  2. Limburg M, Wijdicks EF, Li H. Ischemic stroke after surgical procedures: clinical features, neuroimaging, and risk factors. Neurology 1998; 50: 895–901.

    Article  PubMed  CAS  Google Scholar 

  3. Hogue CW Jr, Murphy SF, Schechtman KB, Davila-Roman VG. Risk factors for early or delayed stroke after cardiac surgery. Circulation 1999; 100: 642–7.

    Article  PubMed  Google Scholar 

  4. Tettenborn B, Caplan LR, Sloan MA, Estol CJ, Pessin MS, DeWitt LD, Haley C, Price TR. Postoperative brainstem and cerebellar infarcts. Neurology 1993; 43: 471–7.

    Article  PubMed  CAS  Google Scholar 

  5. Redmond JM, Greene PS, Goldsborough MA, Cameron DE, Stuart RS, Sussman MS, Watkins L Jr, Laschinger JC, McKhann GM, Johnston MV, Baumgartner WA. Neurologic injury in cardiac surgical patients with a history of stroke. Ann Thorac Surg 1996; 61: 42–7.

    Article  PubMed  CAS  Google Scholar 

  6. Ay H, Buonanno FS, Rordorf G, Schaefer PW, Schwamm LH, Wu O, Gonzalez RG, Yamada K, Sorensen GA, Koroshetz WJ. Normal diffusion-weighted MRI during stroke-like deficits. Neurology 1999; 52: 1784–92.

    Article  PubMed  CAS  Google Scholar 

  7. Hinchey J, Chaves C, Appignani B, Breen J, Pao L, Wang A, Pessin MS, Lamy C, Mas JL, Caplan LR. A reversible posterior leukoencephalopathy syndrome. N Engi J Med 1996; 334: 494–500.

    Article  CAS  Google Scholar 

  8. Wijdicks EF, Plevak DJ, Wiesner RH, Steers JL. Causes and outcome of seizures in liver transplant recipients. Neurology 1996; 47: 1523–5.

    Article  PubMed  CAS  Google Scholar 

  9. Ay H, Buonanno FS, Schaefer PW, Le DA, Wang B, Gonzalez RG, Koroshetz WJ. Posterior leukoencephalopathy without severe hypertension: utility of diffusion-weighted MRI. Neurology 1998; 51: 1369–76.

    Article  PubMed  CAS  Google Scholar 

  10. Mansoor GA, White WB, Grunnet M, Ruby ST. Intracerebral hemorrhage after carotid endarterectomy associated with ipsilateral fibrinoid necrosis: a consequence of the hyperperfusion syndrome? J Vase Surg 1996; 23: 147–51.

    Article  CAS  Google Scholar 

  11. Ross T. Transient tumor attacks. Arch Neurol 1983; 40: 633–6.

    Article  PubMed  CAS  Google Scholar 

  12. Special report from the National Institute of Neurological Disorders and Stroke. Classification of cerebrovascular diseases III. Stroke 1990; 21: 637–76.

    Article  Google Scholar 

  13. Adams HP Jr, Bendixen BH, Kappelle LJ, Biller J, Love BB, Gordon DL, Marsh EE 3d. Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. Stroke 1993; 24: 35–41.

    Article  PubMed  Google Scholar 

  14. Ygge J. Changes in blood coagulation and fibrinolysis during the postoperative period. Am J Surg 1970; 119: 225–32.

    Article  PubMed  CAS  Google Scholar 

  15. Rem J, Feddersen C, Brandt MR, Kehlet H. Postoperative changes in coagulation and fibrinolysis independent of neurogenic stimuli and adrenal hormones. Br J Surg 1981; 68: 2 2933.

    Google Scholar 

  16. Modig J, Borg T, Bagge L, Saldeen T. Role of extradural and of general anaesthesia in fibrinolysis and coagulation after total hip replacement. Br J Anaesth 1983; 55: 625–9.

    Article  PubMed  CAS  Google Scholar 

  17. Kearon C, Hirsh J. Management of anticoagulation before and after elective surgery. N Engl J Med 1997; 336: 1506–11.

    Article  PubMed  CAS  Google Scholar 

  18. Brugieres P, Castrec-Carpo A, Heran F, Goujon C, Gaston A, Marsault C. Magnetic resonance imaging in the exploration of dissection of the internal carotid artery. J Neuroradiol 1989; 16: 1–10.

    PubMed  CAS  Google Scholar 

  19. Gelbert F, Assouline E, Hodes JE, Reizine D, Woimant F, George B, Hagueneau M, Merland JJ. MRI in spontaneous dissection of vertebral and carotid arteries. 15 cases studied at 0.5 tesla. Neuroradiology 1991; 33: 111–3.

    Article  PubMed  CAS  Google Scholar 

  20. Ziser A, Adir Y, Lawn H, Shupak A. Hyperbaric oxygen therapy for massive arterial embolism during cardiac operations. J Thorac Cardiovasc Surg 1999; 117: 818–21.

    Article  PubMed  CAS  Google Scholar 

  21. Young ML, Smith DS, Murtagh F, Vasquez A, Levitt J. Comparison of surgical and anesthetic complications in neurosurgical patients experiencing venous air embolism in the sitting position. Neurosurgery 1986; 18: I57–61.

    Google Scholar 

  22. Moorthy SS, Tisinai KA, Speiser BS, Cikrit DF, Dierdorf SF. Cerebral air embolism during removal of a pulmonary artery catheter. Crit Care Med 1991; 19: 981–3.

    Article  PubMed  CAS  Google Scholar 

  23. Takahashi M, Suzuki R, Osakabe Y, Asai JI, Miyo T, Nagashima G, Fujimoto T, Takahashi Y. Magnetic resonance imaging findings in cerebral fat embolism: Correlation with clinical manifestations. J Trauma 1999; 46: 324–7.

    Article  PubMed  CAS  Google Scholar 

  24. Hofmann S, Huemer G, Salzer M. Pathophysiology and management of the fat embolism syndrome. Anaesthesia 1998; 53 (Suppl 2): 35–7.

    Article  PubMed  Google Scholar 

  25. Byrick RJ, Mullen JB, Mazer CD, Guest CB. Transpulmonary systemic fat embolism. Studies in mongrel dogs after cemented arthroplasty. Am J Respir Crit Care Med 1994; 150: 1416–22.

    Article  PubMed  CAS  Google Scholar 

  26. Chastre J, Fagon JY, Soler P, Fichelle A, Dombret MC, Huten D, Hance AJ, Gibert C. Bronchoalveolar lavage for rapid diagnosis of the fat embolism syndrome in trauma patients. Ann Intern Med 1990; 113: 583–8.

    PubMed  CAS  Google Scholar 

  27. Guenter CA, Braun TE. Fat embolism syndrome. Changing prognosis. Chest 1981; 79: 143–5.

    Article  PubMed  CAS  Google Scholar 

  28. Schwartz MW, McDonald GB. Cholesterol embolization syndrome. Occurrence after intravenous streptokinase therapy for myocardial infarction. JAMA 1987; 258: 1934–5.

    Article  PubMed  CAS  Google Scholar 

  29. Khaffaf N, Karnik R, Winkler WB, Valentin A, Slany J. Embolic stroke by compression maneuver during transcranial Doppler sonography. Stroke 1994; 25: 1056–7.

    Article  PubMed  CAS  Google Scholar 

  30. Bendszus M, Koltzenburg M, Burger R, Warmuth-Metz M, Hofmann E, Solymosi L. Silent embolism in diagnostic cerebral angiography and neurointerventional procedures: a prospective study. Lancet 1999; 354: 1594–7.

    Article  PubMed  CAS  Google Scholar 

  31. Truwit CL, Barkovich AJ, Gean-Marton A, Hibri N, Norman D. Loss of the insular ribbon. Another early sign of acute middle cerebral artery infarction. Radiology 1990; 176: 801–6.

    PubMed  CAS  Google Scholar 

  32. Von Kummer R, Meyding-Lamade U, Forsting M, Rosin L, Rieke K, Hacke W, Sartor K. Sensitivity and prognostic value of early CT in occlusion of the middle cerebral artery trunk. AJNR Am J Neuroradiol 1994; 15: 9–18.

    Google Scholar 

  33. Wardlaw JM, Lewis SC, Dennis MS, Counsel) C, McDowall M. Is visible infarction on computed tomography associated with an adverse prognosis in acute ischemic stroke? Stroke 1998; 29: 1315–9.

    Article  PubMed  CAS  Google Scholar 

  34. Marks MP, Holmgren EB, Fox AJ, Patel S, von Kummer R, Froelich J. Evaluation of early computed tomographic findings in acute ischemic stroke. Stroke 1999; 30: 389–92.

    Article  PubMed  CAS  Google Scholar 

  35. Gonzalez RG, Schaefer PW, Buonanno FS, Schwamm LH, Budzik RF, Rordorf G, Wang B, Sorensen AG, Koroshetz WJ. Diffusion-weighted MR imaging: diagnostic accuracy in patients imaged within 6 hours of stroke symptom onset. Radiology 1999; 210: 155–62.

    PubMed  CAS  Google Scholar 

  36. Katz DA, Marks MP, Napel SA, Bracci PM, Roberts SL. Circle of Willis: evaluation with spiral CT angiography, MR angiography and conventional angiography. Radiology 1995; 195: 445–9.

    PubMed  CAS  Google Scholar 

  37. Wildermuth S, Knauth M, Brandt T, Winter R, Sartor K, Hacke W. Role of CT angiography in patient selection for thrombolytic therapy in acute hemispheric stroke. Stroke 1998; 29: 935–8.

    Article  PubMed  CAS  Google Scholar 

  38. Lövblad KO, Laubach Hi, Baird AE, Curtin F, Schlaug G, Edelman RR, Warach S. Clinical experience with diffusion-weighted MR in patients with acute stroke. AJNR Am J Neuroradiol 1998; 19: 1061–6.

    PubMed  Google Scholar 

  39. van Everdingen KJ, van der Grond J, Kappelle LJ, Ramos LM, Mali WP. Diffusion-weighted magnetic resonance imaging in acute stroke. Stroke 1998; 29: 1783–90.

    Article  PubMed  Google Scholar 

  40. Barber PA, Darby DG, Desmond PM, Gerraty RP, Yang Q, Li T, Jolley D, Donnan GA, Tress BM, Davis SM. Identification of major ischemic change. Diffusion-weighted imaging versus computed tomography. Stroke 1999; 30: 2059–65.

    Article  PubMed  CAS  Google Scholar 

  41. Moseley ME, Kucharczyk J, Mintorovitch J, Cohen Y, Kurhanewicz J, Derugin N, Asgari H, Norman D. Diffusion-weighted MR imaging of acute stroke: correlation with T2-weighted and magnetic susceptibility-enhanced MR imaging in cats. AJNR Am J Neuroradiol 1990; 11: 423–9.

    PubMed  CAS  Google Scholar 

  42. Tong DC, Yenari MA, Albers GW, O’Brien M, Marks MP, Moseley ME. Correlation of perfusion- and diffusion-weighted MRI with NIHSS score in acute (6.5 hour) ischemic stroke. Neurology 1998; 50: 864–70.

    Article  PubMed  CAS  Google Scholar 

  43. Rordorf G, Koroshetz WJ, Copen WA, Cramer SC, Schaefer PW, Budzik RF Jr, Schwamm LH, Buonanno F, Sorensen AG, Gonzalez G. Regional ischemia and ischemic injury in patients with acute middle cerebral artery stroke as defined by early diffusion-weighted and perfusion-weighted MRI. Stroke 1998; 29: 939–43.

    Article  PubMed  CAS  Google Scholar 

  44. Barber PA, Davis SM, Darby DG, Desmond PM, Gerraty RP, Yang O, Jolley D, Donnan GA, Tress BM. Absent middle cerebral artery flow predicts the presence and evolution of the ischemic penumbra. Neurology 1999; 52: 1125–32.

    Article  PubMed  CAS  Google Scholar 

  45. Jansen O, Schellinger P, Fiebach J, Hacke W, Sartor K. Early recanalisation in acute ischaemic stroke saves tissue at risk defined by MRI. Lancet 1999; 353: 2036–7.

    Article  PubMed  CAS  Google Scholar 

  46. Alexandrov AV, Demchuk AM, Wein TH, Grotta JC. Yield of transcranial Doppler in acute cerebral ischemia. Stroke 1999; 30: 1604–9.

    Article  PubMed  CAS  Google Scholar 

  47. Demchuk AM, Christou I, Wein TH, Felberg RA, Malkoff M, Grotta JC, Alexandrov AV. Specific transcranial Doppler flow findings related to the presence and site of arterial occlusion. Stroke 2000; 31: 140–6.

    Article  PubMed  CAS  Google Scholar 

  48. Alexandrov AV, Demchuk AM, Felberg RA, Christou I, Barber PA, Burgin WS, Malkoff M, WojnerAW, Grotta JC. High rate of complete recanalization and dramatic clinical recovery during tPA infusion when continuously monitored with 2-MHz transcranial Doppler monitoring. Stroke 2000; 31: 610–4.

    Article  PubMed  CAS  Google Scholar 

  49. Brandt T, Knauth M, Wildermuth S, Winter R, von Kummer R, Sartor K, Hacke W. CT angiography and Doppler sonography for emergency assessment in acute basilar artery ischemia. Stroke 1999; 30: 606–12.

    Article  PubMed  CAS  Google Scholar 

  50. Rordorf G, Cramer SC, Efird JT, Schwamm LH, Buonanno F, Koroshetz WJ. Pharmacological elevation of blood pressure in acute stroke. Clinical effects and safety. Stroke 1997; 28: 2133–8.

    Article  PubMed  CAS  Google Scholar 

  51. Lavin P. Management of hypertension in patients with acute stroke. Arch Intern Med 1986; 146: 66–8.

    Article  PubMed  CAS  Google Scholar 

  52. Phillips SJ, Whisnant W. Hypertension and the brain. The National High Blood Pressure Education Program. Arch Intern Med 1992; 152: 938–45.

    Article  PubMed  CAS  Google Scholar 

  53. Ringleb PA, Bertram M, Keller E, Hacke W. Hypertension in patients with cerebrovascular accident. To treat or not to treat ? Nephrol Dial Transplant 1998; 13: 2179–81.

    Article  PubMed  CAS  Google Scholar 

  54. Ginsberg MD, Busto R. Combating hyperthermia in acute stroke: a significant clinical concern. Stroke 1998; 29: 529–34.

    Article  PubMed  CAS  Google Scholar 

  55. Castillo J, Davalos A, Marrugat J, Noya M. Timing for fever-related brain damage in acute ischemic stroke. Stroke 1998; 29: 2455–60.

    Article  PubMed  CAS  Google Scholar 

  56. Reith J, Jorgensen HS, Pedersen PM, Nakayama H, Raaschou HO, Jeppesen LL, Olsen TS. Body temperature in acute stroke: relation to stroke severity, infarct size, mortality, and outcome. Lancet 1996; 347: 422–5.

    Article  PubMed  CAS  Google Scholar 

  57. Schwab S, Schwartz S, Spranger M, Keller E, Bertram M, Hacke W. Moderate hypothermia in the treatment of patients with severe middle cerebral artery infarction. Stroke 1998; 29: 2461–6.

    Article  PubMed  CAS  Google Scholar 

  58. Anderson RE, Tan WK, Martin HS, Meyer FB. Effects of glucose and PaO2 modulation on cortical intracellular acidosis, NADH redox state, and infarction in the ischemic penumbra. Stroke I999; 30: 160–70.

    Google Scholar 

  59. Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. N Engl J Med 1995; 333: 1581–7.

    Article  Google Scholar 

  60. Clark WM, Wissman S, Albers GW, Jhamandas JH, Madden KP, Hamilton S. Recombinant tissue- type plasminogen activator (Alteplase) for ischemic stroke 3 to 5 hours after symptom onset. The ATLANTIS study: a randomized controlled trial. Alteplase Thrombolysis for Acute Noninterventional Therapy in Ischemic Stroke. JAMA 1999; 282: 2019–26.

    Article  PubMed  CAS  Google Scholar 

  61. Hacke W, Kaste M, Fieschi C, von Kummer R, Davalos A, Meier D, Larrue V, Bluhmki E, Daavis S, Donnan G, Schneider D, Diez-Tejedor E, Trouillas R Randomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II). Second European-Australasian Acute Stroke Study Investigators. Lancet 1998; 352: 1245–51.

    Article  PubMed  CAS  Google Scholar 

  62. Furlan A, Higashida R, Wechsler L, Gent M, Rowley H, Kase C, Pessin M, Ahuja A, Callahan F, Clark WM, Silver F, Rivera F. Infra-arterial prourokinase for acute ischemic stroke. The PROACT II Study: a randomized controlled trial. Prolyse in Acute Thromboembolism. JAMA 1999; 282: 2003–2011

    Article  PubMed  CAS  Google Scholar 

  63. Hoffmann M, Robbs J. Carotid endarterectomy after recent cerebral infarction. Eur J Vasc Endovasc Surg 1999; 18: 6–10.

    Article  PubMed  CAS  Google Scholar 

  64. Giordano JM. The timing of carotid endarterectomy after acute stroke. Semin Vasc Surg 1998; 11: 19–23.

    PubMed  CAS  Google Scholar 

  65. Paty PS, Darling RC 3rd, Woratyla S, Chang BB, Kreienberg PB, Shah DM. Timing of carotid endarterectomy in patients with recent stroke. Surgery 1997; 122: 850–5.

    Article  PubMed  CAS  Google Scholar 

  66. Qureshi AI, Luft AR, Janardhan V, Suri MF, Sharma M, Lanzino G, Wakhloo AK, Guterman LR, Hopkins LN. Identification of patients at risk for periprocedural neurological deficits associated with carotid angioplasty and stenting. Stroke 2000; 31: 376–82.

    Article  PubMed  CAS  Google Scholar 

  67. Malek A, Higashida RT, Phatouros CC, Lempert TE, Meyers PM, Gress DR, Dowd CF, Halbach VV. Treatment of posterior circulation ischemia with extracranial percutaneous balloon angioplasty and stent placement. Stroke 1999; 30: 2073–85.

    Article  PubMed  CAS  Google Scholar 

  68. Gomez CR, Misra VK, Liu MW, Wadlington VR, Terry JB, Tulyapronchote R, Campbell MS. Elective stenting of symptomatic basilar artery stenosis. Stroke 2000; 31: 95–9.

    Article  PubMed  CAS  Google Scholar 

  69. Ohki T, Roubin GS, Veith FJ, Iyer SS, Brady E. Efficacy of a filter device in the prevention of embolic events during carotid angioplasty and stenting: an ex vivo analysis. J Vasc Surg 1999; 30: 1034–44.

    Article  PubMed  CAS  Google Scholar 

  70. Vishteh AG, Marciano FF, David CA, Schievink WI, Zabramski JM, Spetzler RF. Long-term graft patency rates and clinical outcomes after revascularization for symptomatic traumatic internal carotid artery dissection. Neurosurgery 1998; 43: 761–8.

    Article  PubMed  CAS  Google Scholar 

  71. Koslow AR, Ricotta JJ, Ouriel K, O’Brian M, Green RM, Deweese JA. Reexploration for thrombosis in carotid endarterectomy. Circulation 1989;80:1I173–8.

    Google Scholar 

  72. Dashe JF, Pessin MS, Murphy RE, Payne DD. Carotid occlusive disease and stroke risk in coronary artery bypass graft surgery. Neurology 1997; 49: 678–86.

    Article  PubMed  CAS  Google Scholar 

  73. Low molecular weight heparinoid, ORG 10172 (danaparoid), and outcome after acute ischemic stroke: a randomized controlled trial. The Publications Committee for the Trial of ORG 10172 in Acute Stroke Treatment (TOAST) Investigators. JAMA 1998; 279: 1265–72.

    Article  Google Scholar 

  74. The International Stroke Trial (IST): a randomized trial of aspirin, subcutaneous heparin, both, or neither among 19435 patients with acute ischaemic stroke. International Stroke Trial Collaborative Group. Lancet 1997; 349:1569–81.

    Google Scholar 

  75. McCrory DC, Goldstein LB, Samsa GP, Oddone EZ, Landsman PB, Moore WS, Matchar DB. Predicting complications of carotid endarterectomy. Stroke 1993; 24: 1285–91.

    Article  PubMed  CAS  Google Scholar 

  76. Young B, Moore WS, Robertson JT, Toole JF, Ernst CB, Cohen SN, Broderick JP, Dempsey RJ, Hosking JD. An analysis of perioperative surgical mortality and morbidity in the asymptomatic carotid atherosclerosis study. ACAS Investigators. Asymptomatic Carotid Atherosclerosis Study. Stroke 1996; 27: 2216–24.

    Article  PubMed  CAS  Google Scholar 

  77. John RJ, Choudhri AF, Weinberg AD, Ting W, Rose EA, Smith CR, Oz MC. Multicenter review of preoperative risk factors for stroke after coronary artery bypass grafting. Ann Thorac Surg 2000; 69: 30–6.

    Article  PubMed  CAS  Google Scholar 

  78. Khaitan L, Sutter FP, Goldman SM, Chamogeorgakis T, Wertan MA, Priest BP, Whitlark JD. Simultaneous carotid endarterectomy and coronary revascularization. Ann Thorac Surg 2000; 69: 421–4.

    Article  PubMed  CAS  Google Scholar 

  79. Reed GL 3d, Singer DE, Picard EH, DeSanctis RW. Stroke following coronary-artery bypass surgery. A case-control estimate of the risk from carotid bruits. N Engl J Med 1988; 319: 1246–50.

    Article  PubMed  Google Scholar 

  80. McKhann GM, Goldsborough MA, Borowicz LM Jr, Mellits ED, Brookmeyer R, Quaskey SA, Baumgartner WA, Cameron DE, Stuart RS, Gardner TJ. Predictors of stroke risk in coronary artery bypass patients. Ann Thorac Surg 1997; 63: 516–21.

    Article  PubMed  CAS  Google Scholar 

  81. Brillman J. Central nervous system complications in coronary artery bypass graft surgery. Neurol Clin 1993; 11: 475–95.

    PubMed  CAS  Google Scholar 

  82. Ballotta E, Dagiau G, Saladini M, Bottio T, Abbnrzzese E, Meneghetti G, Guerra M. Results of electroencephalographic monitoring during 369 consecutive carotid artery revascularizations. Eur Neurol 1997; 37: 43–7.

    Article  PubMed  CAS  Google Scholar 

  83. Braekken SK, Reinvang I, Russell D, Brucher R, Svennevig JL. Association between intraoperative cerebral microembolic signals and postoperative neuropsychological deficit: comparison between patients with cardiac valve replacement and patients with coronary artery bypass grafting. J Neurol Neurosurg Psychiatry 1998; 65: 573–6.

    Article  PubMed  CAS  Google Scholar 

  84. Hertzer NR, Loop FD, Beven EG, O’Hara PJ, Krajewski LP. Surgical staging for simultaneous coronary and carotid disease: a study including prospective randomization. J Vasc Surg 1989; 9: 455–63.

    PubMed  CAS  Google Scholar 

  85. Akins CW. Combined carotid endarterectomy and coronary revascularization operation. Ann Thorac Surg 1998; 66: 1483–4.

    Article  PubMed  CAS  Google Scholar 

  86. Cheshire WP, Santos CC, Massey EW, Howard JF Jr. Spinal cord infarction: etiology and outcome. Neurology 1996; 47: 321–30.

    Article  PubMed  CAS  Google Scholar 

  87. Svensson LG, Crawford ES, Hess KR, Coselli JS, Safi HJ. Experience with 1509 patients undergoing thoracoabdominal aortic operations. J Vasc Surg 1993; 17: 357–70.

    Article  PubMed  CAS  Google Scholar 

  88. Cambria RP, Davison JK. Regional hypothermia for prevention of spinal cord ischemic complications after thoracoabdominal aortic surgery: experience with epidural cooling. Semin Thorac Cardiovasc Surg 1998; 10: 61–5.

    PubMed  CAS  Google Scholar 

  89. Acher CW, Wynn MM, Hoch JR, Kramer PW. Cardiac function is a risk factor for paralysis in thoracoabdominal aortic replacement. J Vasc Surg 1998; 27: 821–8.

    Article  PubMed  CAS  Google Scholar 

  90. Faig J, Busse O, Salbeck R. Vertebral body infarction as a confirmatory sign of spinal cord ischemic stroke: report of three cases and review of the literature. Stroke 1998; 29: 239–43.

    Article  PubMed  CAS  Google Scholar 

  91. Bracken MB, Shepard MJ, Holford TR, Leo-Summers L, Aldrich EF, Faz1 M, Fehlings M, Herr DL, Hitchon PW, Marshall LF, Nockels RP, Pascale V, Perot PL Jr, Piepmeier J, Sontag VK, W.gner F, Wilberger JE, Winn FIR, Young W. Administration of methylprednisolone for 24 or 48 hours or tirilazad mesylate for 48 hours in the treatment of acute spinal cord injury. Results of the Third National Acute Spinal Cord Injury Randomized Controlled Trial. National Acute Spinal Cord Injury Study. JAMA 1997; 277: 1597–604.

    Article  PubMed  CAS  Google Scholar 

  92. Hagan PG, Nienaber CA, Isselbacher EM, Bruckman D, Keravite DJ, Russman PL, Evangelista A, Fattori R, Suzuki T, Oh JK, Moore AG, Malouf JF, Pape LA, Gaca C, Sechtem U, Lenferink S, Deutsch HJ, Diedrichs H, Marcos y Robles J, Llovet A, Gilon D, Das SK, Armstrong WF, Deeb GM, Eagle KA. The International Registry of Acute Aortic Dissection (IRAD): new insights into an old disease. JAMA 2000; 283: 897–903.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2001 Springer Science+Business Media New York

About this chapter

Cite this chapter

Oliveira-Filho, J., Koroshetz, W.J. (2001). Ischemic Stroke. In: O’Donnell, J.M., Nácul, F.E. (eds) Surgical Intensive Care Medicine. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-6645-5_14

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-6645-5_14

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-6647-9

  • Online ISBN: 978-1-4757-6645-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics