Skip to main content
SpringerLink
Log in
Book cover

Suki and Massry’s THERAPY OF RENAL DISEASES AND RELATED DISORDERS pp 401–411Cite as

Goodpasture’s Syndrome

  • Chapter

  • 297 Accesses

Abstract

In 1919, Ernest Goodpasture described the case of a young man with a fatal illness characterized by hemoptysis, alveolar hemorrhage and necrosis, and proliferative glomerulonephritis (1). Stanton and Tange, in 1958, were the first to use the eponym Goodpasture’s syndrome to describe cases of pulmonary hemorrhage and necrotizing glomerulonephritis (2), although a large number of similar cases have been reported in the literature since the original description by Goodpasture. The original diagnosis of this syndrome was based on the clinical presence of pulmonary and renal involvement, and the underlying pathology described in literature reports varied. As we have come to understand, such pulmonary-renal syndromes have more than one etiology (Table 1).

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Goodpasture EW: The significance of certain pulmonary lesions in relation to the etiology of influenza. Am J Med Sci 158: 863, 1919.

    Article  Google Scholar 

  2. Stanton MC, Tange JD: Goodpasture’s syndrome: pulmonary hemorrhage associated with glomerulonephritis. Australas Ann Med 7: 132, 1958.

    PubMed  CAS  Google Scholar 

  3. Lindemann W: Sur la mode d’action de certains poisons renaux. Ann Inst Pasteur Immunol 14: 49, 1900.

    CAS  Google Scholar 

  4. Ortega LG, Mellors RC: Analytical pathology IV. The role of localized antibodies in the pathogenesis of nephrotic nephritis in the rat. J Exp Med 104: 151, 1956.

    Article  PubMed  CAS  Google Scholar 

  5. Scheer RL, Grossman MA: Immune aspects of the glomerulonephritis associated with pulmonary hemorrhage. Ann Intern Med 60: 1009, 1964.

    Article  Google Scholar 

  6. Lerner RA, Glssock RJ, Dixon FJ: The role of anti-glomerular basement membrane antibody in the pathogenesis of human glomerulonephritis. J Exp Med 126: 989, 1967.

    Article  PubMed  CAS  Google Scholar 

  7. Davison AM: Seasonal incidence of glomerulonephritis: findings of the UK Medical Research Council’s Glomerulonephritis Registry. Abstracts of IX International Congress of Nephrology, Los Angeles, 1984.

    Google Scholar 

  8. Segelmark M, Butkowski R, Wieslander J: Antigen restriction and IgG subclasses among anti-GBM autoantibodies. Nephrol Dial Transplant 5: 991, 1990.

    Article  PubMed  CAS  Google Scholar 

  9. Savage COS, Noel LH, Pusey CD, et al.: Antiglomerular basement membrane antibody mediated disease in the British Isles 1980–4. Br Med J (Clin Res) 292: 301, 1986.

    Article  CAS  Google Scholar 

  10. Wilson CB: Nephritogenic immune responses involving basement membrane and other antigens in or of the glomerulus. In: NB Cummings, AF Michael, CB Wilson, eds, Immune Mechanisms in Renal Disease. Plenum, New York, p 233, 1983.

    Chapter  Google Scholar 

  11. Benoit FL, Rulon CB, Theil GB, et al.: Goodpasture’s syndrome. A clinicopathologic entity. Am J Med 37: 424, 1964.

    Article  PubMed  CAS  Google Scholar 

  12. Proskey AJ, Weatherbee L, Easterling RE, et al.: Good-pasture’s syndrome. A report of five cases and review of the literature. Am J Med 48: 162, 1970.

    Article  PubMed  CAS  Google Scholar 

  13. Turner N, Lockwood CM, Rees AJ: Antiglomerular basement membrane antibody-mediated nephritis. In: RW Schrier, CW Gottschalk, eds, Diseases of the Kidney, 5th ed. Little, Brown, Boston, p 1865, 1992.

    Google Scholar 

  14. Perez GO, Bjornsonn S, Ross ALI, et al.: A mini epidemic of Goodpasture’s syndrome. Nephron 13: 161, 1974.

    Article  PubMed  CAS  Google Scholar 

  15. Simpson IJ, Doak PB, Williams LC, et al.: Plasma exchange in Goodpasture’s syndrome. Am J Nephrol 2: 301, 1982.

    Article  PubMed  CAS  Google Scholar 

  16. Williams PS, Davenport A, McDicken I, et al.: Increased incidence of anti-glomerular basement membrane antibody (anti-GBM) nephritis in the Mersey region, September 1984-October 1985. Q J Med 68: 727, 1988.

    PubMed  CAS  Google Scholar 

  17. Wilson CB, Smith RC: Goodpasture’s syndrome associated with influenza A2 virus infection. Ann Intern Med 76: 91, 1972.

    Article  PubMed  CAS  Google Scholar 

  18. Wilson CB, Dixon FJ, Evans AS, et al.: Antiviral antibody responses in patients with renal diseases. Clin Immunol Immunopathol 2: 121, 1973.

    Article  PubMed  CAS  Google Scholar 

  19. Beirne GJ, Wagnild JP, Zimmerman SW, et al.: Idiopathic crescentic glomerulonephritis. Medicine 56: 349, 1977.

    Article  PubMed  CAS  Google Scholar 

  20. Wilson CB, Dixon FJ: The renal response to immunologic injury. In: BM Brenner, FC Rector, eds, The Kidney, 3rd ed. Saunders, Philadelphia, p 800, 1986.

    Google Scholar 

  21. Donaghy M, Rees AJ: Cigarette smoking and lung haemorrhage in glomerulonephritis caused by autoantibodies to glomerular basement membrane. Lancet 2: 1390, 1983.

    Article  PubMed  CAS  Google Scholar 

  22. Beirne GJ, Brennan JT: Glomerulonephritis associated with hydrocarbon solvents. Arch Environ Health 25: 365, 1972.

    Article  PubMed  CAS  Google Scholar 

  23. Daniell WE, Couser WG, Rosenstock L: Occupational solvent exposure and glomerulonephritis: a case report and review of the literature. JAMA 259: 2280, 1988.

    Article  PubMed  CAS  Google Scholar 

  24. Nelson NA, Robins TG, Port FK: Solvent nephrotoxicity in humans and experimental animals Am J Nephrol 10: 10, 1990.

    Article  PubMed  CAS  Google Scholar 

  25. D’Apice AJF, Kincaid-Smith P, Becker GJ, et al.: Good-pasture’s syndrome in identical twins. Ann Intern Med 88: 61, 1978.

    Article  PubMed  Google Scholar 

  26. Simonsen H, Brun C, Frokjaer-Thomsen O, et al.: Good-pasture’s syndrome in twins. Acta Med Scand 212: 425, 1982.

    Article  PubMed  CAS  Google Scholar 

  27. Almkuist RD, Buckalew VM, Hirszel P, et al.: Recurrence of anti-glomerular basement membrane antibody mediated glomerulonephritis in an isograft. Clin Immunol Immunopathol 18: 54, 1981.

    Article  PubMed  CAS  Google Scholar 

  28. Burns A, Li P, So A, et al.: HLA class II restrictions in Goodpasture’s syndrome. Nephrol Dial Transplant 5: 297, 1990.

    Google Scholar 

  29. Dunckley H, Chapman JR, Burke J, et al.: HLA-DR and -DQ genotyping in anti-GBM disease. Dis Markers 9: 249, 1992.

    Google Scholar 

  30. Rees AJ, Demaine AG, Welsh KI: Association of immunoglobulin Gm allotypes with antiglomerular basement membrane antibodies and their titre. Hum Immunol 10: 213, 1984.

    Article  PubMed  CAS  Google Scholar 

  31. Relman AS, Dvorak HF, Colvin RB: Case records of the Massachusetts General Hospital: weekly clinicopathological exercises. Case 46–1971. N Engl J Med 285: 1187, 1971.

    Article  Google Scholar 

  32. Wahls TL, Bonsib SM, Schuster VL: Coexistent Wegener’s granulomatosis and anti-glomerular basement membrane disease. Hum Pathol 18: 202, 1987.

    Article  PubMed  CAS  Google Scholar 

  33. Klassen J, Elwood C, Grossberg AL, et al.: Evolution of membranous nephropathy into anti-glomerular-basementmembrane glomerulonephritis. N Engl J Med 290: 1340, 1974.

    Article  PubMed  CAS  Google Scholar 

  34. Moorthy AV, Zimmerman SW, Burkholder PM, et al.: Association of crescentic glomerulonephritits with membranous glomerulonephropathy: a report of three cases. Clin Nephrol 6: 319, 1976.

    PubMed  CAS  Google Scholar 

  35. Richman AI, Rifkin SI, McAllister CJ: Rapidly progressive glomerulonephritis. Combined anti-glomerular basement membrane antibody and immune complex pathogenesis. Hum Pathol 12: 597, 1981.

    Article  PubMed  CAS  Google Scholar 

  36. Weber MF, Andrassy K, Pullig O, et al.: Antineutrophilcytoplasmic antibodies and antiglomerular basement membrane antibodies in Goodpasture’s syndrome and Wegener’s granulomatosis. J Am Soc Nephrol 2: 1227, 1992.

    PubMed  CAS  Google Scholar 

  37. Guerin V, Rabin C, Noel LH, et al.: Anti-glomerular basement membrane disease after lithotripsy. Lancet 1: 856, 1990.

    Article  Google Scholar 

  38. Hudson BG, Kalluri R, Gunwar S, et al.: Molecular characteristics of the Goodpasture autoantigen. Kidney Int 43: 135, 1993.

    Article  PubMed  CAS  Google Scholar 

  39. Butkowski RJ, Langeveld JPM, Wieslander J, et al.: Localization of the Goodpasture epitope to a novel chain of basement membrane collagen. J Biol Chem 262: 7874, 1987.

    PubMed  CAS  Google Scholar 

  40. Saus J, Wieslander J, Langeveld JPM, et al.: Identification of the Goodpasture antigen as the alpha 3 (IV) chain of collagen IV. J Biol Chem 263: 13374, 1988.

    PubMed  CAS  Google Scholar 

  41. Hudson BG, Reeders ST, Tryggvason K: Type IV collagen: structure, gene organization, and role in human diseases. J Biol Chem 268: 26033, 1993.

    PubMed  CAS  Google Scholar 

  42. Kalluri R, Gunwar S, Reeders ST, et al.: Goodpasture syndrome. Localization of the epitope for the autoantibodies to the carboxyl-terminal region of the alpha 3 (IV) chain of basement membrane collagen. J Biol Chem 266: 24018, 1991.

    PubMed  CAS  Google Scholar 

  43. Wieslander J, Langeveld JPM, Butkowski R, et al.: Physical and immunochemical studies of the globular domain of type IV collagen. Cryptic properties of the Goodpasture antigen. J Biol Chem 260: 8564, 1985.

    PubMed  CAS  Google Scholar 

  44. Barker DF, Hostikka SL, Zhou J, et al.: Identification of mutations in the COL4A5 collagen gene in Alport syndrome. Science 248: 1224, 1990.

    Article  PubMed  CAS  Google Scholar 

  45. Kleppel MM, Kashtan C, Santi PA, et al.: Distribution of familial nephritis antigen in normal tissue and renal basement membranes of patients with homozygous and heterozygous Alport familial nephritis. Lab Invest 61: 278, 1989.

    PubMed  CAS  Google Scholar 

  46. Savage COS, Noel LH, Crutcher E, et al.: Hereditary nephritis: immunoblotting studies of the glomerular basement membrane. Lab Invest 60: 613, 1989.

    PubMed  CAS  Google Scholar 

  47. Hudson BG, Kalluri R, Gunwar S, et al.: The pathogenesis of the Alport syndrome involves type IV collagen molecules containing the alpha 3 (IV) chain: evidence from anti-GBM nephritis after renal transplantation. Kidney Int 42: 179, 1993.

    Article  Google Scholar 

  48. Wilson CB: Nephritogenic antibody mechanisms involving antigens within the glomerulus. Immunol Rev 55: 257, 1981.

    Article  PubMed  CAS  Google Scholar 

  49. Wilson CB, Dixon FJ: Anti-glomerular basement membrane antibody-induced glomerulonephritis. Kidney Int 3: 74, 1973.

    Article  PubMed  CAS  Google Scholar 

  50. Jampol LM, Lahar M, Albert DM, et al.: Ocular clinical findings and basement membrane changes in Goodpasture’s syndrome. Am J Ophthalmol 79: 452, 1975.

    PubMed  CAS  Google Scholar 

  51. Turner N, Rees AJ: Anti-glomerular basement membrane disease. In: SJ Cameron, AM Davison, JP Grunfeld, et al., eds, Oxford Textbook of Nephrology. Oxford University Press, Oxford, p 876, 1991.

    Google Scholar 

  52. Gallo GR: Elution studies in kidneys with linear deposition of immunoglobulin in glomeruli. Am J Pathol 61: 377, 1970.

    PubMed  CAS  Google Scholar 

  53. Koffler D, Agnello V, Carr RI, et al.: Variable patterns of immunoglobulin and complement deposition in the kidneys of patients with systemic lupus erythematosus. Am J Pathol 56: 305, 1969.

    PubMed  CAS  Google Scholar 

  54. Querin S, Noel LH, Grunfeld JP, et al.: Linear glomerular IgG fixation in renal allografts: incidence and significance in Alport’s syndrome. Clin Nephrol 25: 134, 1986.

    PubMed  CAS  Google Scholar 

  55. Westberg NG, Michael AF: Immunohistopathology of diabetic glomerulonephritis. Diabetes 21: 163, 1972.

    PubMed  CAS  Google Scholar 

  56. Wilson CB, Dixon FJ: Diagnosis of immunopathologic renal disease. Kidney Im 5: 389, 1974.

    Article  CAS  Google Scholar 

  57. Nowakowski A, Grove RB, King LH, et al.: Goodpasture’s syndrome: recovery from severe pulmonary hemorrhage after bilateral nephrectomy. Ann Intern Med 75: 243, 1971.

    Article  PubMed  CAS  Google Scholar 

  58. Eisinger AJ: Goodpasture syndrome: failure of nephrectomy to cure pulmonary hemorrhage. Am J Med 55: 565, 1973.

    Article  PubMed  CAS  Google Scholar 

  59. Cohen LH, Wilson CB, Freeman RM: Goodpasture’s syndrome: recovery after severe renal insufficiency. Arch Intern Med 136: 835, 1976.

    Article  PubMed  CAS  Google Scholar 

  60. Briggs WA, Johnson JP, Teichman S, et al.: Anti-glomerular basement membrane antibody-mediated glomerulonephritis and Goodpasture’s syndrome. Medicine (Baltimore) 58: 348, 1979.

    CAS  Google Scholar 

  61. Wu MJ, Moorthy AV, Beirne GJ: Relapse in anti-glomerular basement membrane antibody mediated crescentic glomerulonephritis. Clin Nephrol 13: 97, 1980.

    PubMed  CAS  Google Scholar 

  62. Lockwood CM, Rees AJ, Pearson TA, et al Immunosuppression and plasma-exchange in the treatment of Goodpasture’s syndrome. Lancet 1: 711, 1976.

    Article  PubMed  CAS  Google Scholar 

  63. Johnson JP, Moore J, Austin HA, et al.: Therapy of antiglomerular basement membrane antibody disease: analysis of prognostic significance of clinical, pathologic and treatment factors. Medicine (Baltimore) 64: 219, 1985.

    CAS  Google Scholar 

  64. Bolton WK, Sturgill BC: Methylprednisolone therapy for acute crescentic rapidly progressive glomerulonephritis. Am J Nephrol 9: 368, 1989.

    Article  PubMed  CAS  Google Scholar 

  65. Walker RG, Scheinkestel C, Becker GJ, et al.: Clinical and morphological aspects of the management of crescentic anti-glomerular basement membrane antibody (antiGBM) nephritis/Goodpasture’s syndrome. Q J Med 54: 75, 1985.

    PubMed  CAS  Google Scholar 

  66. Querin S, Schurch W, Beaulieu R: Ciclosporin in Good-pasture’s syndrome. Nephron 60: 355, 1992.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Nephrology Department of Medicine, University of Utah School of Medicine, Salt Lake City, 84132, UT, USA

    David I. Charney M.D. (Assistant Professor of Medicine)

  2. Division of Nephrology, University of Utah School of Medicine, Salt Lake City, 84132, UT, USA

    Wayne A. Border M.D. (Professor of Medicine, Chief)

Authors
  1. David I. Charney M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Wayne A. Border M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Wadi N. Suki M.D. Shaul G. Massry M.D.

Rights and permissions

Reprints and permissions

Copyright information

© 1998 Springer Science+Business Media New York

About this chapter

Cite this chapter

Charney, D.I., Border, W.A. (1998). Goodpasture’s Syndrome. In: Suki, W.N., Massry, S.G. (eds) Suki and Massry’s THERAPY OF RENAL DISEASES AND RELATED DISORDERS. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-6632-5_22

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-6632-5_22

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-6634-9

  • Online ISBN: 978-1-4757-6632-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation