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Inhibition of Cell Division and Stimulation of Progesterone Receptor Synthesis in Rat Oestrogen Target Tissues by Non-Steroidal Antioestrogens

  • V. C. Jordan
  • C. J. Dix
  • G. Prestwich
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 117)

Abstract

Tamoxifen and monohydroxytamoxifen (Fig. 1) are non-steroidal compounds that antagonise the effects of oestradiol in the rat (1–4). However, although they are antioestrogenic they also possess atypical oestrogenic activity and are probably best described as partial agonists.

Keywords

Progesterone Receptor Luminal Epithelial Cell Anti Estrogen Action Swing Bucket Rotor Progesterone Receptor Level 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1979

Authors and Affiliations

  • V. C. Jordan
    • 1
  • C. J. Dix
    • 1
  • G. Prestwich
    • 1
  1. 1.Department of Pharmacology, Medical and Dental BuildingUniversity of LeedsLeedsUK

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