Abstract
Since the original identification of cytoplasmic estrogen receptors (ER) in human breast cancer (1), rapid progress has been made towards linking presence of the receptor with endocrine responsiveness of the tumor. It is now known that the likelihood of a successful response to endocrine therapy is increased at least 10-fold in patients whose tumors are positive for ER (2). However, not all ER containing tumors respond, and this has led to the concept that ER are necessary but not sufficient markers of hormone dependence.
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Horwitz, K.B., McGuire, W.L. (1979). Estrogen Control of Progesterone Receptor Induction in Human Breast Cancer: Role of Nuclear Estrogen Receptor. In: Leavitt, W.W., Clark, J.H. (eds) Steroid Hormone Receptor Systems. Advances in Experimental Medicine and Biology, vol 117. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-6589-2_5
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DOI: https://doi.org/10.1007/978-1-4757-6589-2_5
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