Estrogen Control of Progesterone Receptor Induction in Human Breast Cancer: Role of Nuclear Estrogen Receptor

  • Kathryn B. Horwitz
  • William L. McGuire
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 117)


Since the original identification of cytoplasmic estrogen receptors (ER) in human breast cancer (1), rapid progress has been made towards linking presence of the receptor with endocrine responsiveness of the tumor. It is now known that the likelihood of a successful response to endocrine therapy is increased at least 10-fold in patients whose tumors are positive for ER (2). However, not all ER containing tumors respond, and this has led to the concept that ER are necessary but not sufficient markers of hormone dependence.


Estrogen Receptor Nuclear Receptor Estrogen Action Nuclear Site Estrogen Receptor Level 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1979

Authors and Affiliations

  • Kathryn B. Horwitz
    • 1
  • William L. McGuire
    • 1
  1. 1.The University of Texas Health Science CenterSan AntonioUSA

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