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Precocious Puberty in Tay-Sachs Disease

  • Richard Relkin
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 19)

Abstract

Various neurologic causes of sexual precocity have been reported. Among these have been destructive pineal tumors (6,l9,25), hamartomas or hyperplasia of the tuber cinereum (8,14,31), hypothalamic tumors (34,36,40,48,53), tumors of the optic chiasm (12), encephalitis (16), miliary tuberculosis and tuberous sclerosis (55), the Sturge-Weber syndrome, porencephalic cysts, brain damage, craniostenosis, microcephaly, arrested hydrocephalus, and so-called idiopathic cases in which non-specific, but grossly abnormal electroencephalograms have been found (27). In addition, at this institution it has been noted that children with Tay-Sachs disease not uncommonly manifest premature thelarche and/or pubarche (unpublished observations). In an effort to elucidate the pathogenesis of these complete and incomplete forms of precocious puberty, as well as to detect any other hitherto nsuspected hormonal abnormalities, detailed endocrine evaluations of 2 female children with Tay-Sachs disease were carried out.

Keywords

Follicle Stimulate Hormone Plasma Cortisol Precocious Puberty Miliary Tuberculosis Labium Minora 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1972

Authors and Affiliations

  • Richard Relkin
    • 1
  1. 1.Dept. of Medicine & Isaac Albert Research Inst.Kings-brook Jewish Medical CenterBrooklynUSA

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