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Further Studies on Galactocerebroside β-Galactosidase in Globoid Cell Leukodystrophy

  • Kunihiko Suzuki
  • Yoshiyuki Suzuki
  • Thomas F. Fletcher
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 19)

Abstract

The genetic cause underlying globoid cell leukodystrophy (Krabbe’s disease) appears to be the deficiency of galactocerebroside β-galactosidase (galactosylceramide galactosyl hydrolase). Among postmortem organs, the deficiency was initially demonstrated in the brain, liver and spleen from three patients (11). This was later confirmed in the brain, liver and kidney of five additional patients (1, 13). Furthermore, the same deficiency has been demonstrated in peripheral leukocytes (5, 12), serum and cultured fibroblasts (12) from patients afflicted with this fatal neurological disorder. In addition to the diagnostic value of the galactocerebrosidase assay on these easily obtainable materials, our preliminary data indicated the possibility of heterozygous carrier detection utilizing these materials(12).

Keywords

Heterozygous Carrier Peripheral Leukocyte Amniotic Fluid Cell Serum Enzyme Activity Specific Deficiency 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer Science+Business Media New York 1972

Authors and Affiliations

  • Kunihiko Suzuki
    • 1
  • Yoshiyuki Suzuki
    • 1
  • Thomas F. Fletcher
    • 2
  1. 1.Department of NeurologyUniversity of Pennsylvania School of MedicinePhiladelphiaUSA
  2. 2.Department of Veterinary Anatomy College of Veterinary MedicineUniversity of MinnesotaSt. PaulUSA

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