Factors Affecting the Metabolism of Galactocerebroside and Glucocerebroside
Our laboratory has been studying the factors which affect brain cerebroside metabolism through two major approaches: (1) the comparison of enzyme specific activities with various substrates, and (2) the susceptibility of the enzymes to interference by synthetic lipids, analogous in structure to the substrates. The problem is complicated by the existence of the 2-hydroxy group in some of the fatty acids, and the existence of the two clusters of fatty acid chain lengths, around 18 and around 24 carbon atoms.
KeywordsHydroxy Acid Fatty Acid Chain Length Neuronal Perikaryon Chain Base Branched Methyl Group
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