Recent Advances in Metachromatic Leukodystrophy

  • E. Neuwelt
  • D. Stumpf
  • J. Austin
  • P. Kohler
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 19)


Metachromatic leukodystrophy (MLD) is a fatal neurolipidosis characterized pathologically by both central and peripheral demyelination. It is genetically-determined as an autosomal recessive. MLD is caused by a deficiency of cerebroside sulfatase (arylsulfatase A; E.C.3.1.6.)(3), a lysosomal hydrolase responsible for the catabolism of sulfatide. Its substrate, cerebroside sulfate (sulfatide), is one of the key glycolipids in the myelin sheath.


Contact Inhibition Identical Monomer Hybrid Polymer Metachromatic Leukodystrophy Normal Enzyme 


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Copyright information

© Springer Science+Business Media New York 1972

Authors and Affiliations

  • E. Neuwelt
    • 1
  • D. Stumpf
    • 1
  • J. Austin
    • 1
  • P. Kohler
    • 1
  1. 1.Divisions of Neurology and Clinical ImmunologyUniversity of Colorado Medical CenterDenverUSA

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