Abstract
In his review on sphingolipidoses (1) which appeared in the New England Journal of Medicine in 1966, R.O. Brady predicted that a sphingolipodystrophy remains to be discovered where abnormal quantities of the entire globoside molecule might accumulate because of attenuation of a hexosaminidase that catalyses the hydrolysis of the terminal N-acetylgalactosamine.
This paper includes the presentations of H. Jatzkewitz and K. Sandhoff: “The Chemical Pathology of Tay-Sachs Disease”, and of K. Sandhoff and H. Jatzkewitz: “Characterization of Two Human Hexosaminidases Involved in Tay-Sachs Disease”.
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References
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Sandhoff, K., Jatzkewitz, H. (1972). The Chemical Pathology of Tay-Sachs Disease. In: Volk, B.W., Aronson, S.M. (eds) Sphingolipids, Sphingolipidoses and Allied Disorders. Advances in Experimental Medicine and Biology, vol 19. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-6570-0_22
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DOI: https://doi.org/10.1007/978-1-4757-6570-0_22
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