Interaction of Enzymes with Lipid Substrates
The recent five to eight years have been characterized by major advances in the enzymology of the complex lipids. This might be exemplified by the characterization of the enzymes which synthesize and degrade the sphingolipids; the identification of separate phospholipases Al and A2; the identification of a new pathway for phosphoglyceride biosynthesis via acyl dihydroxyacetone phosphate and further recognition of the enzymes which synthesize and degrade the glycerophosphatides. A further major advance, pertinent to this symposium, is the recognition that the sphingolipid storage diseases are caused by defects in degradative enzymes. In contrast to this rapid development, identification of the mechanisms of action of these enzymes has been extremely slow. Only scanty information is available to date on the mode of interaction of the enzymes with their respective lipid substrates, either in vivo or in vitro.
KeywordsSubstrate Concentration Enzyme Concentration Aggregation Number Critical Micellar Concentration Soluble Enzyme
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