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Interaction of Enzymes with Lipid Substrates

  • Shimon Gatt
  • Yechezkel Barenholz
  • Ilana Borkovski-Kubiler
  • Zelina Leibovitz-Ben Gershon
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 19)

Abstract

The recent five to eight years have been characterized by major advances in the enzymology of the complex lipids. This might be exemplified by the characterization of the enzymes which synthesize and degrade the sphingolipids; the identification of separate phospholipases Al and A2; the identification of a new pathway for phosphoglyceride biosynthesis via acyl dihydroxyacetone phosphate and further recognition of the enzymes which synthesize and degrade the glycerophosphatides. A further major advance, pertinent to this symposium, is the recognition that the sphingolipid storage diseases are caused by defects in degradative enzymes. In contrast to this rapid development, identification of the mechanisms of action of these enzymes has been extremely slow. Only scanty information is available to date on the mode of interaction of the enzymes with their respective lipid substrates, either in vivo or in vitro.

Keywords

Substrate Concentration Enzyme Concentration Aggregation Number Critical Micellar Concentration Soluble Enzyme 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1972

Authors and Affiliations

  • Shimon Gatt
    • 1
  • Yechezkel Barenholz
    • 1
  • Ilana Borkovski-Kubiler
    • 1
  • Zelina Leibovitz-Ben Gershon
    • 1
  1. 1.Department of BiochemistryThe Hebrew University-Hadassah Medical SchoolJerusalemIsrael

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