Purification and Properties of Two Sphingolipid Hydrolases
Our understanding of the lipid storage disorders has progressed dramatically since 1881 when Warren Tay, a British opthalmologist, described a cherry-red macular degeneration in the fundus of an infant with marked weakness of the trunk and limbs (1). This patient was the first reported case of Tay-Sachs disease. In the 90 years that have followed, there has been a delineation of a large number of inherited met abolic disorders characterized by the accumulation within tissues of large amounts of lipids.
KeywordsSodium Cholate Amniotic Fluid Cell Acetone Fraction Decyl Sulfate Sphingomyelinase Activity
Unable to display preview. Download preview PDF.