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A New Aids Therapy Approach Using Magnetoliposomes

  • Detlef Müller-Schulte
  • Frank Füssl
  • Heiko Lueken
  • Marcel De Cuyper
Chapter

Abstract

A new concept for the treatment of the AIDS infection is described whereby a simple heat treatment is used to irreversibly inactivate the AIDS virus. The temperatures of more than 50°C required for the virus inactivation are achieved by inductively heating magnetoliposomes (ML) designed for in vivo administration. To ensure that the heat is transferred solely to the HIV and not to the adjacent tissue, the ML are pre-coated with CD4 receptor molecules, thus enabling a close attachment of the ML to the HIV via its gp 120 envelope protein. This process corresponds to the in vivo HIV infection pathway. To assess the feasibility of the new approach, serum albumin and IgG were used as model proteins for the CD4 receptor and successfully coupled to ML. Induction heating experiments with diverse ML suspensions and magnetic colloids clearly demonstrated that the magnetic particles can be selectively heated up to the required temperatures.

Keywords

Human Immunodeficiency Virus Type Lauric Acid Magnetic Fluid Inductive Heating Chromotropic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Detlef Müller-Schulte
    • 1
  • Frank Füssl
    • 1
  • Heiko Lueken
    • 1
  • Marcel De Cuyper
    • 2
  1. 1.Institut für Anorganische ChemieRWTH AachenAachenGermany
  2. 2.Campus KortrijkKatholieke Universiteit LeuvenKortrijkBelgium

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