New Method of Biological Fluid Detoxification Based on Magnetic Adsorbents
Existing methods of human organism detoxification such as hemoperfusion, hemodialysis and plasmapheresis are of low efficiency, damage cellular elements of blood, and require a significant volume of blood, complex and expensive hardware. We used finely dispersed magnetic adsorbents for hemosorption. A suspension of such particles, injected into an extracorporeal system, moves with the bloodstream and leads, due to the large specific surface of the magnetic adsorbents, to a fast and effective sorption process. The small size of the particles and very short and simple extracorporeal system does not damage cellular blood elements. Magnetic particles are then removed by a high gradient magnetic separator and the purified blood is returned to the organism. Effectiveness of the method was tested, and adsorbents for low, medium and high molecular weight compounds were selected. Animal experiments showed the high effectiveness of the technique for the removal of low-molecular weight toxins (barbiturates).
KeywordsHigh Sorption Capacity High Molecular Weight Compound Magnetic Adsorbent Sorption Column High Gradient Magnetic Separator
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