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New Method of Biological Fluid Detoxification Based on Magnetic Adsorbents

  • Michael V. Kutushov
  • Anatoly A. Kuznetsov
  • Victor I. Filippov
  • Oleg A. Kuznetsov
Chapter

Abstract

Existing methods of human organism detoxification such as hemoperfusion, hemodialysis and plasmapheresis are of low efficiency, damage cellular elements of blood, and require a significant volume of blood, complex and expensive hardware. We used finely dispersed magnetic adsorbents for hemosorption. A suspension of such particles, injected into an extracorporeal system, moves with the bloodstream and leads, due to the large specific surface of the magnetic adsorbents, to a fast and effective sorption process. The small size of the particles and very short and simple extracorporeal system does not damage cellular blood elements. Magnetic particles are then removed by a high gradient magnetic separator and the purified blood is returned to the organism. Effectiveness of the method was tested, and adsorbents for low, medium and high molecular weight compounds were selected. Animal experiments showed the high effectiveness of the technique for the removal of low-molecular weight toxins (barbiturates).

Keywords

High Sorption Capacity High Molecular Weight Compound Magnetic Adsorbent Sorption Column High Gradient Magnetic Separator 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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    Gorchakov VD, Sergienko VI, Vladimirov VG (1989). Selective adsorbents. Moscow, Medicina.Google Scholar
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    Kuznetsov AA, Filippov VI, Kutushov MA et al (1991). Russian patent #4955558/14.Google Scholar
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    Kuznetsov AA, Filippov VI, Kutushov MA et al (1989). USSR patent #4677768/30–14.Google Scholar
  4. 4.
    Kuznetsov AA, Harutyunyan AR, Dobrinsky EK et al (1997). Ferro-carbon Particles: Preparation and Clinical Applications. This book.Google Scholar

Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Michael V. Kutushov
    • 1
  • Anatoly A. Kuznetsov
    • 2
  • Victor I. Filippov
    • 2
  • Oleg A. Kuznetsov
    • 2
  1. 1.Sklifosofsky Institute of Emergency MedicineMoscowRussia
  2. 2.Institute of Biochemical PhysicsRussian Academy of SciencesMoscowRussia

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