Poly-C Binding Proteins: Cellular Regulators of mRNA Fate and Function

  • Andrea V. Gamarnik
  • Raul Andino
Part of the Endocrine Updates book series (ENDO, volume 16)


Cellular mRNAs are subjected to multiple levels of regulation, and an increasing number of RNA-binding proteins that control mRNA function have been identified. Recently, several laboratories showed that a family of proteins called poly(rC) binding proteins, PCBPs, play important roles in translation regulation and mRNA stabilization. PCBPs are RNA binding proteins that contain three copies of a conserved RNA binding domain called KH also found in other RNA binding proteins such as hnRNP K (1). PCBPs are involved in both normal cellular mRNA metabolism and in the regulation of viral RNA utilization. Here we will review the recent advances in PCBP function in cellular and viral RNA metabolism as well as structure determinants for RNA recognition. We will discuss possible mechanisms by which PCBPs may control different aspects of mRNA fate, including subcellular localization, regulation of translation, RNA stability as well as the role of PCBP in viral RNA replication.


Viral Translation Tyrosine Hydroxylase mRNA Translational Silence mRNA Fate Quiescent Hepatic Stellate Cell 
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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Andrea V. Gamarnik
    • 1
  • Raul Andino
    • 2
  1. 1.Instituto de Investigaciones BioquimicasBuenos AiresArgentina
  2. 2.University of CaliforniaSan FranciscoUSA

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