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Regulation of G-Protein Coupled Receptor Cytosolic mRNA Binding Proteins

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RNA Binding Proteins

Part of the book series: Endocrine Updates ((ENDO,volume 16))

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Abstract

The regulation of G-protein coupled receptor (GPCR) expression is an area of intense interest because GPCRs play a crucial role in many key physiological and pathological processes. Indeed, greater than 60% of all pharmaceuticals are targeted towards GPCRs. The ability to regulate GPCR protein expression at the post-transcriptional level provides a mechanism past the transcriptional regulatory point when genes are turned on or off. This allows a finer control of expression for the GPCRs that are critically involved in a myriad of critical cell functions such as growth, differentiation, and development. In the majority of instances of post-transcriptional regulation, the binding of specific proteins to defined sequences and/or structures in the target mRNA, governs splicing, nucleocytoplasmic transport, subcellular localization, translation and mRNA degradation. In this chapter, we focus on the regulation of GPCRs via cytosolic RNA binding proteins that, through interaction with specific sequences or structures in the mRNA, contribute to determining the level of protein expression by altering the rate of mRNA translation or its stability. Highlighted are our studies on RNA binding proteins that interact with the 5’ leader sequence of the angiotensin AT1 receptor, a GPCR that is critical to the control of blood pressure and fluid homeostasis.

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Authors and Affiliations

  1. Georgetown University School of Medicine, Washington, DC, USA

    Kathryn Sandberg, Zheng Wu, Hong Ji, Eric Hernandez & Susan E. Mulroney

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  1. Kathryn Sandberg
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  4. Eric Hernandez
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Editors and Affiliations

  1. Departments of Medicine and Physiology & Biophysics, Georgetown University School of Medicine, Washington, DC, USA

    Kathryn Sandberg Ph.D. (Associate Professor) (Associate Professor)

  2. Department of Physiology & Biophysics, Georgetown University School of Medicine, Washington, DC, USA

    Susan E. Mulroney Ph.D. (Associate Professor) (Associate Professor)

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Sandberg, K., Wu, Z., Ji, H., Hernandez, E., Mulroney, S.E. (2002). Regulation of G-Protein Coupled Receptor Cytosolic mRNA Binding Proteins. In: Sandberg, K., Mulroney, S.E. (eds) RNA Binding Proteins. Endocrine Updates, vol 16. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-6446-8_17

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  • DOI: https://doi.org/10.1007/978-1-4757-6446-8_17

  • Publisher Name: Springer, Boston, MA

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