Skip to main content
SpringerLink
Log in

Analysis of Health Effects Caused by Multiple Insults

  • Chapter
Risk Assessment and Management

Part of the book series: Advances in Risk Analysis ((AIRA,volume 5))

  • 424 Accesses

Abstract

A method is presented for the analysis of the risk of health effects caused by a combination of insults. The approach is entirely phenomenological and has no built-in restrictions. Also, interactions between the effects of various toxicants are treated in a general manner. The only restrictions arise from the finite set of functions relating exposure parameters and the risk of health effects. As an example, the incidences of oral and esophageal cancer in man are analyzed as a function of alcohol and tobacco consumption. The properties of the solutions obtained are discussed, together with conclusions about the processes involved in the etiology of these cancers.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Reif, A.E., Synergism in Carcinogenesis, JNCI, 73, 25–39, 1984.

    PubMed  CAS  Google Scholar 

  • Seiler, F.A., Oral and Esophageal Cancer and the Consumption of Alcohol and Tobacco, Inhalation Toxicology Research Institute, Annual Report 1983–1984, LMF-113, p. 327–331, 1984, available from National Technical Information Service, Springfield, VA, 22161; and to be published.

    Google Scholar 

  • Tuyns, A.J., G. Peuquignot, and D.M. Jensen, Le Cancer de l’Oesophage en Ille-et-Villaine en Function des Niveaux de Consummation d’Alcool et de Tabac: Des Risques qui se Multiplient, Bulletin du Cancer, 64, 4560, 1977.

    Google Scholar 

  • Walter, S.D., Prevention of Multifactorial Disease, Am. J. Epidemiol., 112, 409–416, 1980.

    PubMed  CAS  Google Scholar 

  • Whittemore, A.S., and A. McMillan, Lung Cancer Mortality Among U.S. Uranium Miners: A Reappraisal, JNCI, 71, 489–499, 1983.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Lovelace Inhalation Toxicology Research Institute, Albuquerque, NM, 87185, USA

    Fritz A. Seiler

Authors
  1. Fritz A. Seiler
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Carnegie-Mellon University, Pittsburgh, Pennsylvania, USA

    Lester B. Lave

Rights and permissions

Reprints and permissions

Copyright information

© 1987 Springer Science+Business Media New York

About this chapter

Cite this chapter

Seiler, F.A. (1987). Analysis of Health Effects Caused by Multiple Insults. In: Lave, L.B. (eds) Risk Assessment and Management. Advances in Risk Analysis, vol 5. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-6443-7_4

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-6443-7_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-6445-1

  • Online ISBN: 978-1-4757-6443-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation