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Plasticity Mechanisms Underlying mGluR-Induced Epileptogenesis

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Recent Advances in Epilepsy Research

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 548))

Abstract

Transient application of group I metabotropic glutamate receptor (mGluR) agonists to hippocampal slices produces ictal-like discharges that persist for hours after the removal of the agonist. This effect of group I mGluR stimulation—converting a ‘normal’ hippocampal slice into an ‘epileptic-like’ one—may represent a form of epileptogenesis. Because this epileptogenic process can be induced in vitro and it occurs within hours, it has been possible to examine the cellular and transduction processes underlying the generation and long-term maintenance of ictal-like bursts. ImctuR(v) a voltage-dependent depolarizing current activated by group I mGluR agonists, appears to play an important role in the expression of the ictal-like bursts. Long-term activation of ImG1uR(v) following mGluR stimulation is a possible plastic change that enables the long-term maintenance of ictal discharges. Induction of ImGltaz(v) may represent a cellular event underlying the mGluR-induced epileptogenesis.

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Authors
  1. Robert K. S. Wong
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  2. Shih-Chieh Chuang
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  3. Riccardo Bianchi
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Editor information

Editors and Affiliations

  1. Department of Neurological Surgery, Moffitt Hospital, University of California at San Francisco, San Francisco, California, USA

    Devin K. Binder

  2. Center for Neural Recovery and Rehabilitation Research, New York State Department of Health, Helen Hayes Hospital, West Haverstraw, New York, USA

    Helen E. Scharfman

  3. Departments of Pharmacology and Neurology, Columbia University, New York, New York, USA

    Helen E. Scharfman

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© 2004 Springer Science+Business Media New York

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Wong, R.K.S., Chuang, SC., Bianchi, R. (2004). Plasticity Mechanisms Underlying mGluR-Induced Epileptogenesis. In: Binder, D.K., Scharfman, H.E. (eds) Recent Advances in Epilepsy Research. Advances in Experimental Medicine and Biology, vol 548. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-6376-8_5

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  • DOI: https://doi.org/10.1007/978-1-4757-6376-8_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4419-3418-5

  • Online ISBN: 978-1-4757-6376-8

  • eBook Packages: Springer Book Archive

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