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How Many Subjects are Required for a Trial?

  • Christopher J. Bulpitt
Part of the Developments in Biostatistics and Epidemiology book series (DBEP, volume 1)

Abstract

The number of subjects required for a controlled trial depends on the major objective defined for the trial; the level of significance that must be achieved if the objective is reached; the confidence with which a negative result should be reported if the objective is not reached; and the variability of the end-point measurements.

Keywords

Percent Level Nominal Level Pragmatic Trial Explanatory Trial Normal Deviate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media Dordrecht 1983

Authors and Affiliations

  • Christopher J. Bulpitt
    • 1
    • 2
    • 3
  1. 1.Department of Medical Statistics and EpidemiologyLondon School of Hygiene and Tropical MedicineLondonUK
  2. 2.Royal Postgraduate Medical SchoolLondonUK
  3. 3.Hammersmith HospitalLondonUK

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