The DNA Content of Epidermal Cell Nuclei in Pseudocarcinomatous Hyperplasia and in Squamous Cell Carcinoma
Proliferation of the epidermis, as of any other tissue, is inextricably linked up with the metabolism of nucleic acids, which are responsible for the storage, transfer, and translation of genetic information. The key roles in cell reproduction, genetic information transmission, and malignant transformation are played by deoxyribonucleic acid (DNA) which makes up the chromosomes. A strict correlation is now known to exist between the number of chromosomes in a cell nucleus and the amount of DNA in the nucleus (e. g. Atkin, 1962; Caspersson, 1964; Levan, 1967). As the number of chromosomes in the nucleus doubles in preparation for mitosis, so does the amount of DNA, and the variation in nuclear DNA content can therefore give an indication of variation in chromosome number (Atkin, 1962; James, 1962).
KeywordsSquamous Cell Carcinoma Basal Cell Carcinoma Nuclear Area Epidermal Hyperplasia Suprabasal Cell
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