Changes in brain monoaminergic systems in apomorphine-sensitized aggressive male Wistar rats
Apomorphine, an unselective dopamine Dl and D2 receptor agonist, induces in laboratory animals (mice and rats), several behavioural phenomena such as stereotyped behaviour, hyperlocomotion, aggressiveness, etc 1–3. The apomorphine-induced (0.5–1.0 mg/kg, once or twice daily during 10–15 days) aggression has been considered to be an animal model of human psychotic behaviour4,5. This hypothesis is evidenced by the fact that most of the psychotropic drugs used in clinical practice for the treatment of psychosis attenuate or completely block the apomorphine-induced aggression in adult male Wistar rats. Though the mechanisms of action of those drugs are known, the neurobiology of the apomorphine-induced aggression is not well understood6.
KeywordsHigh Pressure Liquid Chromatography Monobasic Sodium Phosphate Aggressive Posture Octanesulfonic Acid Neurochemical Analysis
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