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The role of serotonin in the modulation of aggression

Studies using tryptophan manipulation
  • Alyson J. Bond
  • Janet Wingrove
Chapter

Abstract

Serotonin has been shown to have a major role in the modulation of aggressive behaviour in both animals and humans. An inverse relationship between indices of serotonergic function and impulsive aggressive behaviour has been repeatedly displayed but much of the evidence is correlational. A direct method of acutely manipulating levels of the neurotransmitter, serotonin, is by tryptophan depletion (TD). A drink containing large neutral amino acids but excluding tryptophan has been shown to substantially lower both tryptophan in the plasma and tissues and the rate of serotonin synthesis in the brain1. This technique has been used to investigate changes in anger and aggression.

Keywords

Acute Tryptophan Depletion Tryptophan Depletion Serotonin Synthesis Large Neutral Amino Acid Serotonergic Function 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Nishizawa, S., Benkelfat,C., Young, S.N., Leyton, M., Mzengeza, S, De Montigny, C., Blier, P., and Diksic, M., 1997, Differences between males and females in rates of serotonin synthesis in human brain. Proc. Natl. Acad Sci. 94: 5308–5313.Google Scholar
  2. 2.
    Bjork, J.M., Dougherty, D.M., Moeller, F.G., Cherek, D.R., and Swann, A.C., 1999, The effects of tryptophan depletion and loading on laboratory aggression in men: time course and a food-restricted control. Psychopharmacology 142: 24–30.PubMedCrossRefGoogle Scholar
  3. 3.
    Bjork, J.M., Dougherty, D.M., Moeller, F.G., and Swann, A.C., 2000, Differential behavioral effects of plasma trytophan depletion and loading in aggressive and nonaggressive men. Neuropsychopharmacology 22: 357–369.PubMedCrossRefGoogle Scholar
  4. 4.
    Salomon, R.M., Mazure, C.M., Delgado, P.L., Mendia, P., and Charney, D.S., 1994, Serotonin function in aggression: the effect of acute plasma tryptophan depletion in aggressive patients. Biol. Psychiatry 35: 570–572.PubMedCrossRefGoogle Scholar
  5. 5.
    Cleare, A.J., and Bond, A.J., 1994, Effects of alterations in plasma tryptophan levels on aggressive feelings. Arch Gen. Psychiatry 51: 1004–1005.PubMedCrossRefGoogle Scholar
  6. 6.
    Cleare, A.J., and Bond, A.J., 1995, The effect of tryptophan depletion and enhancement on subjective and behavioural aggression in normal male subjects. Psychopharmacology 118: 72–81.PubMedCrossRefGoogle Scholar
  7. 7.
    Finn, P.R., Young, S.N., Pihl, R.O., and Ervin, F.R., 1998, The effects of acute plasma tryptophan manipulation on hostile mood: the influence of trait hostility. Aggress. Behay. 24: 173–185.CrossRefGoogle Scholar
  8. 8.
    Wingrove, J., Bond, A.J., and Cleare, A.J., 1999, Tryptophan enhancement/depletion and reactions to failure on a cooperative computer game. Neuropsychopharmacology 21: 755–764.PubMedCrossRefGoogle Scholar
  9. 9.
    Pihl, R.O., Young, S.N., Harden, P., Plotnick, S., Chamberlain, B., and Ervin, F.R., 1995, Acute effect of altered tryptophan levels and alcohol on aggression in normal human males. Psychopharmacology 119: 353–360.PubMedCrossRefGoogle Scholar
  10. 10.
    Moeller, F.G., Dougherty, D.M., Swarm, A.C., Collins, D., Davis, C.M. and Cherek, D.R., 1996, Tryptophan depletion and aggressive responding in healthy males. Psychopharmacology 126: 97–103.PubMedCrossRefGoogle Scholar
  11. 11.
    Dougherty, D.M., Bjork, J.M., Marsh, D.M., and Moeller, F.G., 1999, Influence of trait hostility on tryptophan depletion-induced laboratory aggression. Psychiatry Res. 88: 227–232.PubMedCrossRefGoogle Scholar
  12. 12.
    Smith, S.E., Pihl, R.O., Young, S.N., and Ervin, F.R., 1986, Elevation and reduction of plasma tryptophan and their effects on aggression and perceptual sensitivity in normal males. Aggress. Behay. 12: 393–407.CrossRefGoogle Scholar
  13. 13.
    Williams, R.B., 1994, Neurobiology, cellular and molecular biology, and psychosomatic medicine.Psychosom Med 56: 308–315.Google Scholar
  14. 14.
    Rogers, RD., Everitt, B.J., Baldacchino, A., Blackshaw, A.J., Swainson, R., Wynne, K., Baker, N.B., Hunter, J., Carthy, T., Booker, E., London, M., Deakin, J.F.W., Sahakian, B.J., and Robbins, T.W., 1999, Dissociable deficits in the decision-making cognition of chronic amphetamine abusers, patients with focal damage to prefrontal cortex, and tryptophan-depleted normal volunteers: evidence for monoaminergic mechanisms. Neuropsychopharmacology 20: 322–339.PubMedCrossRefGoogle Scholar
  15. 15.
    Newman, M.E., Shapira, B., and Lerer, B., 1998, Evaluation of central serotonergic function in affective and related disorders by the fenfluramine challenge test: a critical review. Int. J. Neuropsychopharmacology 1: 49–69.CrossRefGoogle Scholar
  16. 16.
    Cleare, A.J., and Bond, A.J., 2000, Experimental evidence that the aggressive effect of tryptophan depletion is mediated via the 5-HT,A receptor. Psychopharmacology, 147: 439–441.PubMedCrossRefGoogle Scholar
  17. 17.
    Ratey, J. Sovner, R., Parks, A., and Rogentine K., 1991, Buspirone treatment of aggression and anxiety in mentally retarded patients: a multiple-baseline, placebo lead-in study. J Clin. Psychiatry 52: 159–162.Google Scholar
  18. 18.
    Cocarro, E.F. and Kavoussi, R.J., 1997, Fluoxetine and impulsive aggressive behavior in personality-disordered subjects. Arch. Gen. Psychiatry 54: 1081–1088.CrossRefGoogle Scholar
  19. 19.
    Raleigh, M.J, McGuire M.T, Brammer, G.L., Pollack, D.B. and Yuwiler, A., 1991, Serotonergic mechanisms promote dominance acquisition in adult male vervet monkeys. Brain Research 559: 181–190.PubMedCrossRefGoogle Scholar
  20. 20.
    Knutson. B., Wolkowitz, O.M., Cole, S.W., Chan., T., Moore, E.A., Johnson, R.C., Terpstra, J., Turner, R.A., and Reus, V.L., 1998, Selective alteration of personality and social behaviour by serotonergic intervention. Am. J. Psychiatry 155: 373–379.Google Scholar

Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Alyson J. Bond
    • 1
  • Janet Wingrove
    • 1
  1. 1.Section of Clinical Psychopharmacology, Institute of PsychiatryKing’s CollegeLondonUK

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