Development and Validation of Multiwavelength Algorithms for in Vivo Near Infrared Spectroscopy
The ability to measure changes in tissue oxygenation noninvasively is of potential benefit to managing a variety of problems in clinical medicine. One useful way to assess tissue oxygenation in situ. is to measure oxygen-dependent light absorption by hemoglobin and other chromophores present in the tissues. Soft tissues and bone are relatively translucent to near infrared (NIR) photons and three important biological molecules, hemoglobin (Hb+Hb02), myoglobin (Mb+Mb02) and oxidized cytochrome c oxidase (cyt a, a.3) have oxygen-dependent absorption spectra in the 700–900 nm wavelength region. Therefore, NIR spectroscopy offers a potential solution to the problem of noninvasive measurement of changes in tissue oxygenation. These concepts were first reported from Duke University in 1977 when Jöbsis1 demonstrated a “window” for transmission of NIR light in biological tissues and the feasibility of in vivo NIR monitoring of changes in the oxygenation state of hemoglobin and the oxidation level of cyt a, a3 in the brain. Continuous, noninvasive NIR monitoring techniques to evaluate tissue oxygenation have evolved gradually over the past 10 years at Duke and other institutions2–4.
KeywordsMigration Catheter Ischemia Assure Washout
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