Metastatic Carcinoma in the Ovary

  • Ancel Blaustein


The ovary is a fairly frequent site of metastasis from certain primary carcinomas; approximately 10% of ovarian tumors are not primary in origin.5,8,9,18,21 The most common metastasis is from a carcinoma arising in the endometrium. Other primary tumors that have a predeliction for metastasis to the ovary are from the gastrointestinal (GI) tract1 and breast.4,10 Tumors that metastasize to the ovary much less frequently include those arising in the cervix, fallopian tube, pancreas, gallbladder, lung, and cutaneous melanoma. A study of secondary ovarian carcinoma by Woodruff and Novak21 demonstrated that at least 50% of the primary tumors giving rise to ovarian metastases were below the diaphragm and 13% above. Metastatic carcinoma to the ovary is bilateral in from 70 to 90% of cases6,8,21; unilateral involvement usually is found where metastasis occurs by contiguity. There are, however, instances of unilateral metastases that are difficult to explain, e.g., from the breast or the GI tract.


Breast Carcinoma Ovarian Carcinoma Fallopian Tube Carcinoid Tumor Endometrial Carcinoma 


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  1. 1.
    Burt, C. A. V. Prophylactic oophorectomy with resection of the large bowel for cancer. Am. J. Surg. 93: 77, 1957.Google Scholar
  2. 2.
    Esau, D. Krukenberg tumoren in der schwangerschaft. Nachtrag zu der arbeit von Dr. Puppel, Zentvalbl f. Gynak. 57: 1167, May 1933.Google Scholar
  3. 3.
    Finn, W. F. Diagnostic confusion of ovarian metastases from endometrial carcinoma with primary ovarian carcinoma. Am. J. Obstet. Gynecol. 62: 403, 1951.Google Scholar
  4. 4.
    Haagerson, C. D. Diseases of the Breast, 2nd ed. Philadelphia, W. B. Saunders, 1971.Google Scholar
  5. 5.
    Haines, M. Carcinoid tumors of the ovary. J. Obstet. Gynaecol. Br. Commonw. 78: 1123, 1971.Google Scholar
  6. 6.
    Hall-Allan, R. T. J. Metastatic ovarian carcinoid tumor. Postgrad. Med. J. 45: 46, 1969.Google Scholar
  7. 7.
    Hopping, R. A., Dockerty, M. B., and Masson, J. C. Carcinoid tumors of the appendix—report of a case in which extensive intraabdominal metastases occurred, including involvement of the right ovary. Arch. Surg. 45: 613, 1942.CrossRefGoogle Scholar
  8. 8.
    Israel, S. S., Helsel, E. V., Jr., and Hausman, D. H. The challenge of metastatic ovarian carcinoma. Am. J. Obstet. Gynecol. 93: 1094, 1965.PubMedGoogle Scholar
  9. 9.
    Karsh, J. Secondary malignant disease of the ovary. Am. J. Obstet. Gynecol. 61: 154, 1951.Google Scholar
  10. 10.
    Kasilag, F. B., Jr., and Ruthledge, F. N. Metastatic breast carcinoma of the ovary. Am. J. Obstet. Gynecol. 74: 989, 1957.Google Scholar
  11. 11.
    Krukenberg, P. Ueben das Fibrosarcoma Ovarii Muco-cellulari (carcinomatoses). Arch. Gyn. Munch. 50: 287, 1896.CrossRefGoogle Scholar
  12. 12.
    Lee, Y. N., and Hori, J. M. Significance of ovarian metastasis in therapeutic oophorectomy for advanced breast cancer. Cancer 27: 1374, 1971.PubMedCrossRefGoogle Scholar
  13. 13.
    Martzloff, K. H., and Manlove, C. H. Vaginal and ovarian metastases from hypernephroma: Report of a case and review of literature. Surg. Gynecol. Obstet. 88: 145, 1949.Google Scholar
  14. 14.
    Munnell, E. W., and Taylor, H. C., Jr. Ovarian carcinoma: Review of 200 primary and 51 secondary cases. Am. J. Obstet. Gynecol. 58: 943, 1949.PubMedGoogle Scholar
  15. 15.
    Ober, W. B., Pollak, A., Gerstmann, K. E., and Kupperman, H. S. Krukenberg tumor with androgenic and progestational activity. Am. J. Obstet. Gynecol. 84: 739, 1962.PubMedGoogle Scholar
  16. 16.
    Robboy, S. J., Scully, R. E., and Norris, H. T. Carcinoidmetastatic to the ovary. Cancer 33: 798, 1974.PubMedCrossRefGoogle Scholar
  17. 17.
    Schlagenhaufer, F. Uber das Metastatische Ovarialkarzinom Nach Krebs das Magens, Darmes and anderer Bachorgane. Mschv. Geburtsh Gyak. 15: 485, 1902.Google Scholar
  18. 18.
    Scully, R. E. Recent progress of ovarian cancer. Hum. Pathol. 1: 73, 1970.Google Scholar
  19. 19.
    Shuster, M., Mendoza-Divino, E., and Joelson, H. Carcinoid tumor metastasizing to the ovaries. Obstet. Gynecol. 36: 515, 1970.Google Scholar
  20. 20.
    Turenen, K. Hormonal secretion of Krukenberg tumors. Acta Endocrinol. 20: 50, 1955.Google Scholar
  21. 21.
    Woodruff, J. D., and Novak, E. R. Krukenberg tumors of the ovary. Obstet. Gynecol. 15: 351, 1960.PubMedGoogle Scholar
  22. 22.
    Woodruff, J. D., Williams, J. J., and Goldberg, B. Hormone activity of the common ovarian neoplasms. Am. J. Obstet. Gynecol. 87: 679, 1963.Google Scholar

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© Springer Science+Business Media New York 1977

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  • Ancel Blaustein

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