Germ Cell Tumors of the Ovary

  • A. Talerman
  • M. R. C. Path


This group of ovarian neoplasms is composed of a number of histologically different tumor types and embraces all the neoplasms considered to be ultimately derived from the primitive germ cells of the embryonic gonad. The concept of germ cell tumors as a specific group of gonadal neoplasms has evolved in the last three decades and has become generally accepted. This concept is based primarily on the common histogenesis of these neoplasms, on the relatively frequent presence of histologically different tumor elements within the same tumor mass, on the presence of histologically similar neoplasms in extra-gonadal locations along the line of migration of the primitive germ cells from the wall of the yolk sac to the gonadal ridge,244 and on the remarkable homology between the various tumor types in the male and the female. In no other group of gonadal neoplasms is this homology better illustrated. Although the strong morphologic resemblance between the testicular seminoma and its ovarian counterpart the dysgerminoma was noted soon after these neoplasms were first described, for a long time there was no agreement as to their histogenesis. Nevertheless, these were the first neoplasms to become accepted as originating from germ cells. However, it was not until the studies by Teilum212,213 on the homology of ovarian and testicular neoplasms, the studies by Friedman and Moore66 and Dixon and Moore,52 on testicular tumors, and those by Friedman65 on related extragonadal neoplasms that the germ cell origin of other neoplasms belonging to this group was suggested. These views were supported by the embryologic studies by Witschi244 and Gillman,70 and later by the experimental work of Stevens198–200 and Pierce and his collaborators156 158,161,162 on germ cell tumors in rodents. The histogenesis and the interrelationship of the various types of germ cell neoplasms as has been suggested by Teilum217 is shown in Figure 26.1.


Germ Cell Germ Cell Tumor Embryonal Carcinoma Cystic Teratoma Immature Teratoma 


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  1. 1.
    Abell, M. R., Johnson, V. J., and Holtz, F. Ovarian neoplasms in childhood and adolescence. Part 1. Tumors of germ cell origin. Am. J. Obstet. Gynecol. 92: 1059, 1965.PubMedGoogle Scholar
  2. 2.
    Abitol, M. M., Pomerance, W., and Mackles, A. Spontaneous intraperitoneal rupture of benign cystic teratomas. Review of literature and report of two cases. Obstet. Gynecol. 13: 198, 1959.CrossRefGoogle Scholar
  3. 3.
    Albrechtsen, R., Klee, J. G., and Moller, J. E. Primary intra-cranial germ cell tumours, including five cases of endodermal sinus tumour. Acta Pathol. Microbiol. Scand. 80A Suppl., 233: 32, 1972.Google Scholar
  4. 4.
    Allard, S., Cadotte, M., and Boivin, Y. Dysgenesie gonadique pure familiale et gonadoblastome. L’Union Medicale du Canada 101: 448, 1972.Google Scholar
  5. 5.
    Andersen, M. C., and Mc.Dicken, I. W. Melanotic cyst of the ovary. J. Obstet. Gynaecol. Br. Commw. 78: 1047, 1971.CrossRefGoogle Scholar
  6. 6.
    Ansfield, F. J., Korbitz, B. C., Davis, H. L., and Ramirez, G. Triple drug therapy in testicular tumors. Cancer 24: 442, 1969.PubMedCrossRefGoogle Scholar
  7. 7.
    Arhelger, R. B., and Kelly, B. Strumal carcinoid. Report of a case with electron microscopical observations. Arch. Pathol. 97: 323, 1974.Google Scholar
  8. 8.
    Asadourian, L. A., and Taylor, H. B. Dysgerminoma. An analysis of 105 cases. Obstet. Gynecol. 33: 370, 1969.Google Scholar
  9. 9.
    Azoury, R. S., Jubayli, N. W., and Barakat, B. Y. Dermoid cyst of the ovary containing fetus-like structure. Obstet. Gynecol. 42: 887, 1973.Google Scholar
  10. 10.
    Azzopardi, J. G., and Hou, L. T. Intestinal metaplasia with argentaffin cells in cervical adenocarcinoma. J. Pathol. Bacterial. 90: 686, 1965.Google Scholar
  11. 11.
    Bagg, H. J. Experimental production of teratoma testis in a fowl. Am. J. Cancer 26: 69, 1936.Google Scholar
  12. 12.
    Ballas, M. Yolk sac carcinoma of the ovary with alphafetoprotein in serum and ascitic fluid demonstrated by immunoosmophoresis. Am. J. Clin. Pathol. 57: 511, 1972.Google Scholar
  13. 13.
    Ballas, M. The significance of alpha-fetoprotein in the serum of patients with malignant teratomas and related gonadal neoplasms. Am. J. Clin. Lab. Sci. 4: 267, 1974.Google Scholar
  14. 14.
    Bardin, C. W., Rosen, S., Le Maire, W. J., Tjio, J. H., Gallup, J., Marshall, J., and Savard, K. In vivo and in vitro studies of androgen metabolism in a patient with pure gonadal dysgenesis and Leydig cell hyperplasia. J. Clin. Endocrinol. Metab. 29:1429, 1968.Google Scholar
  15. 15.
    Barry, K. G., and Crosby, W. H. Autoimmune hemolytic anemia arrested by removal of ovarian teratoma: Review of the literature and report of a case. Ann. Int. Med. 47: 1002, 1957.PubMedCrossRefGoogle Scholar
  16. 16.
    Bartlett, D. J., Grant, J. K., Pugh, M. A., and Aherne, W. A familial feminizing syndrome. A family showing intersex characteristics with XY chromosomes in three female members. J. Obstet. Gynaecol. Brit. Commw. 75: 199, 1968.Google Scholar
  17. 17.
    Beck, J. S., Fulmer, H. F., and Lee, S. T. Solid malignant ovarian teratoma with “embryoid bodies” and trophoblastic differentiation. J. Pathol. 99: 67, 1969.PubMedCrossRefGoogle Scholar
  18. 18.
    Beilby, J. O. W., and Todd, P. J. Yolk sac tumour of the ovary. J. Obstet. Gynaecol. Brit. Commw. 81: 90, 1974.Google Scholar
  19. 19.
    Berg, J. W., and Baylor, S. M. The epidemiologic pathology of ovarian cancer. Hum. Pathol. 4: 537, 1973.Google Scholar
  20. 20.
    Bergher de Bacalao, E., and Dominguez, I. Unilateral gonadoblastoma in a pregnant woman. Am. J. Obstet. Gynecol. 105: 1279, 1969.Google Scholar
  21. 21.
    Bergstrand, C. G., and Czar, B. Demonstration of a new protein fraction in serum from human fetus. Scand. J. Lab. Invest. 8: 174, 1956.CrossRefGoogle Scholar
  22. 22.
    Bernstein, D., Naor, S., Rikover, M., and Manahem, H. Hemolytic anemia related to ovarian tumor. Obstet. Gynecol. 43: 276, 1974.PubMedGoogle Scholar
  23. 23.
    Bestle, J. Extragonadal endodermal sinus tumours originating in the region of the pineal gland. Acta Pathol. Microbiol. Scand. 74: 214, 1968.CrossRefGoogle Scholar
  24. 24.
    Bettinger, H. F., and Jacobs, H. Mesonephroma ovarii. Med. J. Aust. 1: 100, 1948.Google Scholar
  25. 25.
    Blackwell, W. J., Dockerty, M. B., Masson, J. C., and Mussey, R. D. Dermoid cysts of the ovary; clinical and pathological significance. Am. J. Obstet. Gynecol. 51: 151, 1946.PubMedGoogle Scholar
  26. 26.
    Boczkowski, K., Teter, J., and Sternadel, Z. Sibship occurrence of XY gonadal dysgenesis with dysgerminoma. Am. J. Ob-stet. Gynecol. 113: 952, 1972.Google Scholar
  27. 27.
    Borushek, S., Berger, I., Echt, C., and Gold, J. J. Functioning malignant germ cell tumor of the ovary in a 41/2 year old girl. Cancer 18: 1485, 1965.PubMedCrossRefGoogle Scholar
  28. 28.
    Braunstein, H., Stephens, C. L., and Gibson, R. L. Secretory granules in medullary carcinoma of the thyroid. Electronmicroscopic demonstration. Arch. Pathol. 85: 306, 1968.Google Scholar
  29. 29.
    Breen, J. L., and Neubecker, R. D. Malignant teratoma of the ovary. An analysis of 17 cases. Obstet. Gynecol. 21: 669, 1963.Google Scholar
  30. 30.
    Breen, J. L., and Neubecker, R. D. Ovarian malignancy in children with special reference to the germ cell tumors, in Weyer, E. H., ed.: Pediatric and Adolescent Gynecology. Ann. N.Y. Acad. Sci. 142:658, 1967.Google Scholar
  31. 31.
    Brody, S. Clinical aspects of dysgerminoma of the ovary. Acta Radiol. (Stockholm) 56: 209, 1961.Google Scholar
  32. 32.
    Cabanne, F. Gonadoblastomes et tumeurs de l’ebauche gonadique. Ann. Anat. Pathol. (Paris) 16: 387, 1971.Google Scholar
  33. 33.
    Carleton, R. L., Friedman, N. B., and Bomze, E. J. Experimental teratomas of testis. Cancer 6: 464, 1953.PubMedCrossRefGoogle Scholar
  34. 34.
    Caruso, P. A., Marsh, M. R., Minkowitz, S., and Karten, G. An intense clinicopathologic study of 305 teratomas of the ovary. Cancer 27: 343, 1971.PubMedCrossRefGoogle Scholar
  35. 35.
    Chenot, M. Contribution à l’étude des épithéliomas primitifs de l’ovaire. Thesis, Paris, 1911.Google Scholar
  36. 36.
    Chevassu, M. Tumeurs du Testicule. Thesis, Steinhall, Paris, 1906.Google Scholar
  37. 37.
    Chretien, P. B., Milam, J. D., Foote, F. W., and Miller, T. R. Embryonal adenocarcinomas (a type of malignant teratoma) of the sacrococcygeal region. Clinical and pathologic aspects of 21 cases. Cancer 26: 522, 1970.PubMedCrossRefGoogle Scholar
  38. 38.
    Climie, A. R., and Heath, L. P. Malignant degeneration of benign cystic teratoma of the ovary. Review of the literature and report of a chondrosarcoma and a carcinoid tumor. Cancer 22: 824, 1968.PubMedCrossRefGoogle Scholar
  39. 39.
    Collins, D. H., and Symington, T. Sertoli cell tumour, in Collins, D. H., and Pugh, R. C. B., eds.: The Pathology of Testicular Tumours. Edinburgh and London, Livingstone Ltd., 1965, pp. 52–61.Google Scholar
  40. 40.
    Cooperman, L. R., Hamlin, J., and Elmer, N. Gonadoblastoma: A rare ovarian tumor with characteristic roentgen appearance. Radiology 90: 322, 1968.Google Scholar
  41. 41.
    Corfman, P. A., and Richart, R. M. Chromosome number and morphology of benign cystic teratomas. New Engl. J. Med. 271: 1241, 1964.Google Scholar
  42. 42.
    Cutler, B. S., Forbes, A. P., Ingersoll, F. M., and Scully, R. E. Endometrial carcinoma after stilbestrol therapy in gonadal dysgenesis. New Engl. J. Med. 287: 628, 1972.Google Scholar
  43. 43.
    Dalgaard, J. B., and Wetteland, P. Struma ovarii. A follow-up study of 20 cases. Acta Chir. Scand. 112: 1, 1956.Google Scholar
  44. 44.
    Damjanov, I., Drobnjak, P., and Grizelj, V. Ultrastructure of gonadoblastoma. Arch. Pathol. 99: 25, 1975.Google Scholar
  45. 45.
    Dandia, S. D. Rectovesical fistula following an ovarian dermoid with recurrent vesical calculus. A case report. J. Urol. 97: 85, 1967.PubMedGoogle Scholar
  46. 46.
    Davidsohn, I., Kovarik, S., and Stejskal, R. Immunological aspects. Influence of prognosis and treatment, in Gentil, F., and Junqueira, A. C., eds.: Ovarian Cancer. U.I.C.C. Monograph Se-ries, Vol. 11. Berlin, Heidelberg, New York, Springer-Verlag, 1968, pp. 105–121.CrossRefGoogle Scholar
  47. 47.
    Dawson, M. A., Wilimer, T., and Yarbro, J. W. Hemolytic anemia associated with an ovarian tumor. Am. J. Med. 50: 552, 1971.CrossRefGoogle Scholar
  48. 48.
    De Haan, Q. C. Non-gestational choriocarcinoma of the ovary. Obstet. Gynecol. 26: 708, 1965.Google Scholar
  49. 49.
    De Lima, F. A. O. Disgerminoma do Ovario, contribucao para o seo estudo anatomo-clinico. Thesis, Sao Paulo, Brazil, 1966.Google Scholar
  50. 50.
    Dikman, S. H., and Toker, C. Strumal carcinoid of the ovary with musculinization. Cancer 27: 925, 1971.PubMedCrossRefGoogle Scholar
  51. 51.
    Diligent, E. Gonadoblastomes et dysgenesies pseudogonadoblastiques. Thesis, Nancy, 1971.Google Scholar
  52. 52.
    Dixon, F. J., and Moore, R. A. Tumors of the Male Sex Organs. Atlas of Tumor Pathology, Sect. VIII, Fasc. 31b and 32. Washington, D.C., Armed Forces Institute of Pathology, 1952.Google Scholar
  53. 53.
    Duhig, J. T. An unusual adenocarcinoma of the ovary. Am. J. Obstet. Gynecol. 77: 201, 1959.Google Scholar
  54. 54.
    Duval, M. Le placenta de rongeurs. J. Anat. Physiol. (Paris) 27: 515, 1891.Google Scholar
  55. 55.
    Emge, L. A. Functional and growth characteristics of struma ovarii. Am. J. Obstet. Gynecol. 40: 738, 1940.Google Scholar
  56. 56.
    Engel, T., Greeyley, A. V., and Sweeney, W. J. III. Recurrent dermoid cysts of the ovary. Report of 2 cases. Obstet. Gynecol. 26: 757, 1965.Google Scholar
  57. 57.
    Erez, S. E., Richart, R. M., and Shettles, L. B. Hashimoto’s disease in a benign cystic teratoma of the ovary. Am. J. Obstet. Gynecol. 92: 273, 1965.PubMedGoogle Scholar
  58. 58.
    Evans, R. W. Developmental stages of embryo-like bodies in teratoma testis. J. Clin. Pathol. 10: 31, 1957.Google Scholar
  59. 59.
    Evans, R. W. Histological Appearances of Tumours, 2nd ed. Edinburgh and London, Livingstone, 1966.Google Scholar
  60. 60.
    Ewing, J. Neoplastic Diseases, 4th ed. Philadelphia, W. B. Saunders, 1940, pp. 641, 672.Google Scholar
  61. 61.
    Felmus, L. B., and Pedowitz, P. Clinical malignancy of endocrine tumors of the ovary and dysgerminoma. Obstet. Gynecol. 29: 344, 1968.Google Scholar
  62. 62.
    Forney, J. P., Di Saia, P. J., and Morrow, C. P. Endodermal sinus tumor. A report of two sustained remissions treated postoperatively with a combination of actinomycin D, 5-fluorouracil and cyclophosphamide. Obstet. Gynecol. 45: 186, 1975.PubMedGoogle Scholar
  63. 63.
    Fox, H., Kazzaz, B., and Langley, F. A. Argyrophil and argentaffin cells in the female genital tract and in ovarian mucinous cysts. J. Pathol. Bacteriol. 88: 479, 1964.PubMedCrossRefGoogle Scholar
  64. 64.
    Frazier, S. D., Bashore, R. A., and Mosier, H. D. Gonadoblastoma associated with pure gonadal dysgenesis in monozygous twins. J. Pediatr. 64: 740, 1964.Google Scholar
  65. 65.
    Friedman, N. B. The comparative morphogenesis of extragenital and gonadal teratoid tumors. Cancer 4: 265, 1951.PubMedCrossRefGoogle Scholar
  66. 66.
    Friedman, N. B., and Moore, R. A. Tumors of the testis. A report of 922 cases Mil. Surgeon 99: 573, 1946.Google Scholar
  67. 67.
    Galager, H. S., and Lewis, R. P. Sequential gonadoblastoma and choriocarcinoma. Obstet. Gynecol. 41: 123, 1973.Google Scholar
  68. 68.
    Galton, M., and Benirschke, K. 46 chromosomes in an ovarian teratoma. Lancet 2: 761, 1959.PubMedCrossRefGoogle Scholar
  69. 69.
    Gans, B., Bahary, C., and Levie, B. Ovarian regeneration and pregnancy following massive radiotherapy for dysgerminoma. Report of a case. Obstet. Gynecol. 22: 596, 1963.PubMedGoogle Scholar
  70. 70.
    Gillman, J. The development of the gonads in man with consideration of the role of fetal endocrines and the histogenesis of ovarian tumors. Contrib. Embryo]. 32: 83, 1948.Google Scholar
  71. 71.
    Gitlin, D., and Boesman, M. Sites of serum alpha-fetoprotein synthesis in the human and in the rat. J. Clin. Invest. 46: 1010, 1967.PubMedCrossRefGoogle Scholar
  72. 72.
    Gitlin, D., and Pericelli, A. Synthesis of serum albumin, pre-albumin, alpha-fetoprotein, alpha-1-antitrypsin, and transfer-rin by the human yolk sac. Nature 228: 995, 1970.PubMedCrossRefGoogle Scholar
  73. 73.
    Gitlin, D., Pericelli, A., and Gitlin, G. Synthesis of alphafetoprotein by liver, yolk sac and gastro-intestinal tract of the human conceptus. Cancer Res. 32: 979, 1972.Google Scholar
  74. 74.
    Goldstein, D. P., and Piro, J. A. Combination chemotherapy in the treatment of germ cell tumors containing choriocarcinoma. Surg. Gynecol. Obstet. 134: 61, 1972.Google Scholar
  75. 75.
    Gondos, B., Bhiraleus, P., and Hobel, C. J. Ultrastructural observations on germ cells in human fetal ovaries. Am. J. Obstet. Gynecol. 110: 644, 1971.Google Scholar
  76. 76.
    Gonzalez-Angulo, A., Kaufman, R., Braungardt, C. D., Chapman, F. C., and Hinshaw, A. J. Adenocarcinoma of thyroid arising in struma ovarii (malignant struma ovarii). Report of two cases and review of the literature. Obstet. Gynecol. 21: 567, 1963.Google Scholar
  77. 77.
    Gonzalez-Licea, A., Hartman, W. H., and Yardley, J. H. Medullary carcinoma of the thyroid. Ultrastructural evidence of its origin from the parafollicular cell and its possible relation to carcinoid tumors. Am. J. Clin. Pathol. 49: 512, 1968.PubMedGoogle Scholar
  78. 78.
    Griffiths, K., Grant, J. K., Browning, N. C. K., Whyte, W. G., and Sharp, J. L. Steroid synthesis in vitro by tumor tissue from dysgenetic gonad. J. Endocrinol. 34: 155, 1966.Google Scholar
  79. 79.
    Grosfeld, J. L., Stepita, D. S., Nance, W. E., and Palmer, C. G. Fetus-in-Fetu. An unusual cause for an abdominal mass in infancy. Ann. Surg. 180: 80, 1974.Google Scholar
  80. 80.
    Gusberg, S. B., and Danforth, D. N. Clinical significance of struma ovarii. Am. J. Obstet. Gynecol. 48: 537, 1944.Google Scholar
  81. 81.
    Hain, A. M. An unusual case of precocious puberty associated with ovarian dysgerminoma. J. Clin. Endocrinol. 9: 1349, 1949.Google Scholar
  82. 82.
    Hameed, K., and Burslem, M. R. G. A melanotic ovarian neoplasm resembling the “retinal anlage” tumor. Cancer 25: 564, 1970.PubMedCrossRefGoogle Scholar
  83. 83.
    Hertig, A. T., and Adams, C. E. Studies on the human oocyte and its follicle. 1. Ultrastructural and histochemical observations on primordial follicle stage. J. Cell. Biol. 34: 647, 1967.PubMedCrossRefGoogle Scholar
  84. 84.
    Hertig, A. T., and Gore, H. Tumors of the female sex organs. Part 3. Tumors of the ovary and Fallopian tube. Atlas of Tumor Pathology, Section 9, Fasc. 33. Washington D.C., Armed Forces Institute of Pathology, 1961.Google Scholar
  85. 85.
    Higuchi, K., and Kato, T. Dysgerminoma of the ovary. J. Jap. Obstet. Gynecol. Soc. 5: 206, 1958.Google Scholar
  86. 86.
    Hingorani, V., Narula, R. K., and Bhalla, S. Salmonella typhi infection in an ovarian dermoid. Report of a case. Obstet. Gynecol. 22: 118, 1963.Google Scholar
  87. 87.
    Hou, L. T., and Azzopardi, J. G. Muco-epidermoid metaplasia and argentaffin cells in nephroblastoma. J. Pathol. Bacteriol. 93: 477, 1967.PubMedCrossRefGoogle Scholar
  88. 88.
    Hou-Jensen, K., and Kempson, R. L. The ultrastructure of gonadoblastoma and dysgerminoma. Hum. Pathol. 5: 79, 1974.PubMedCrossRefGoogle Scholar
  89. 89.
    Hughesdon, P. E. Two cases of struma ovarii showing the histogenesis of thyroid and thymus in ovarian teratoma. J. Pathol. Bacterial. 70: 35, 1955.Google Scholar
  90. 90.
    Hughesdon, P. E., and Kumarasamy, T. Mixed germ cell tumors (gonadoblastomas) in normal and dysgenetic gonads. Virchow’s Arch. Pathol. Anat. 349: 258, 1970.Google Scholar
  91. 91.
    Huntington, R. W. Jr., and Bullock, W. K. Yolk sac tumors of the ovary. Cancer 25: 1357, 1970.PubMedCrossRefGoogle Scholar
  92. 92.
    Huntington, R. W. Jr., and Bullock, W. K. Yolk sac tumors of extragonadal origin. Cancer 25: 1368, 1970.PubMedCrossRefGoogle Scholar
  93. 93.
    Huntington, R. W. Jr., Morgenstern, N. L., Sargent, J. A., Giem, R. N., Richards, A., and Hanford, K. C. Germinal tumors exhibiting the endodermal sinus pattern of Teilum in young children. Cancer 16: 34, 1963.PubMedCrossRefGoogle Scholar
  94. 94.
    Itoh, T., Shirai, T., Naka, A., and Matsumoto, S. Yolk sac tumor and alpha-fetoprotein: Clinicopathological study of four cases. Gann 65: 215, 1974.Google Scholar
  95. 95.
    Jackson, S. M. Ovarian dysgerminoma. Brit. J. Radio]. 40: 459, 1967.CrossRefGoogle Scholar
  96. 96.
    Janovski, N. A., and Paramanandhan, T. L. Ovarian tumors. Tumors and tumor-like conditions of the ovaries, Fallopian tubes and ligaments of the uterus. Stuttgart, Georg Thieme, 1973.Google Scholar
  97. 97.
    Jatoi, A. F. Dysgerminoma of the ovary (A study of 23 cases). J. Postgrad. Med. 5: 22, 1959.Google Scholar
  98. 98.
    Jedberg, H. Some clinical aspects of dysgerminoma ovarii. Acta Obstet. Gynecol. Scand. 28: 194, 1949.CrossRefGoogle Scholar
  99. 99.
    Judd, H. L., Scully, R. E., Atkins, L., Neer, R. M., and Kliman, B. Pure gonadal dysgenesis with progressive hirsutism. New Engl. J. Med. 282: 881, 1970.Google Scholar
  100. 100.
    Kawahara, H.: Struma ovarii with ascites and hydrothorax. Am. J. Obstet. Gynecol. 85: 85, 1963.PubMedGoogle Scholar
  101. 101.
    Kay, S., Silverberg, S. G., and Schatzki, P. F. Ultrastructure of an ovarian dysgerminoma. Report of a case featuring neurosecretory-type granules in stromal cells. Am. J. Clin. Pathol. 58: 458, 1972.Google Scholar
  102. 102.
    Kazancigil, T. R., Laquer, W., and Ladewig, P. Papilloendothelioma of the ovary; report of three cases and discussion of Schiller’s “mesonephroma ovarii”. Am. J. Cancer 40: 199, 1940.Google Scholar
  103. 103.
    Kelley, R. R., and Scully, R. E. Cancer developing in dermoid cysts of the ovary. A report of 8 cases including a carcinoid and a leiomyosarcoma. Cancer 14: 989, 1961.PubMedCrossRefGoogle Scholar
  104. 104.
    Koller, O., and Gjonnes, H. Dysgerminoma of the ovary. Acta Obstet. Gynecol. Scand. 43: 268, 1964.Google Scholar
  105. 105.
    Larson, N. E., Dockerty, M. B., and Pratt, J. H. Primary mixed choriocarcinoma and dysgerminoma of the ovary. Report of a case. Proc. Mayo Clinic 33: 341, 1958.Google Scholar
  106. 106.
    Levine, G. D. Primary thymic seminoma-a neoplasm ultrastructurally similar to testicular seminoma and distinct from epithelial thymoma. Cancer 31: 729, 1973.PubMedCrossRefGoogle Scholar
  107. 107.
    Liebert, K. I., and Stent, L. Dysgerminoma of the ovary with chorionepithelioma. J. Obstet. Gynaecol. Brit. Emp. 77: 627, 1960.CrossRefGoogle Scholar
  108. 108.
    Linder, D. Gene loss in human teratomas. Proc. Natl. Acad. Sci. U.S. 63: 699, 1969.Google Scholar
  109. 109.
    Linder, D., and Power, J. Further evidence for postmeiotic origin of teratomas in the human female. Ann. Hum. Genet. 34: 21, 1970.CrossRefGoogle Scholar
  110. 110.
    Linder, D., McCaw, B. K., and Hecht, F. Parthenogenic origin of benign ovarian teratoma. New Engl. J. Med. 292: 63, 1975.Google Scholar
  111. 111.
    Lingeman, C. H. Etiology of cancer of the human ovary. A review. J. Natl. Cancer Inst. 53: 1603, 1974.Google Scholar
  112. 112.
    Lord, J. M. Intra-abdominal foetus in fetu. J. Pathol. Bacteriol. 72: 627, 1956.CrossRefGoogle Scholar
  113. 113.
    Lynn, J. A., Varon, H. H., Kingsley, W. B., and Martin, J. H. Ultrastructure and biochemical studies of estrogen-secreting capacity of a “non-functional” ovarian neoplasm (dysgerminoma). Am. J. Pathol. 51: 639, 1967.Google Scholar
  114. 114.
    Mackay, A. M., Pattigrew, N., Symington, T., and Neville, A. M. Tumors of dysgenetic gonads (gonadoblastoma). Ultrastructural and steroidogenic aspects. Cancer 34: 1108, 1974.Google Scholar
  115. 115.
    McCullough, C. D., and Hardart, F. Neuroblastomatous transformation in a benign cystic teratoma. Obstet. Gynecol. 21: 259, 1963.Google Scholar
  116. 116.
    McDonough, P. G., Greenblatt, R. B., Byrd, J. R., and Hastings, E. V. Gonadoblastoma (Gonocytoma III). Report of a case. Obstet. Gynecol. 29: 54, 1967.Google Scholar
  117. 117.
    McKay, D. G., Hertig, A. T., Adams, E. C., and Danziger, S. Histochemical observations on the germ cells of human embryos. Anat. Rec. 117: 201, 1953.Google Scholar
  118. 118.
    McKay, D. G., Pinkerton, J. H. M., Hertig, A. T., and Danziger, S. The adult human ovary: A histochemical study. Ob-stet. Gynecol. 18: 13, 1961.Google Scholar
  119. 119.
    Malkasian, G. D. Jr., Dockerty, M. B., and Symmonds, R. E. Benign cystic teratomas. Obstet. Gynecol. 29: 719, 1967.Google Scholar
  120. 120.
    Malkasian, G. D. Jr., and Symmonds, R. E. Treatment of the unilateral encapsulated germinoma. Am. J. Obstet. Gynecol. 90: 379, 1964.Google Scholar
  121. 121.
    Malkasian, G. D. Jr., Symmonds, R. E., and Dockerty, M. B. Malignant ovarian eratomas. Report of 31 cases. Obstet. Gynecol. 25: 810, 1965.PubMedGoogle Scholar
  122. 122.
    Malkasian, G. D. Jr., Webb, M. J., and Jorgensen, E. O. Observations on chemotherapy of granulosa cell carcinoma and malignant ovarian teratoma. Obstet. Gynecol. 44: 885, 1974.Google Scholar
  123. 123.
    Marcial-Rojas, R. A., and de Arellano, R. G. A. Malignant melanoma arising in a dermoid cyst of the ovary. Cancer 9: 523, 1956.PubMedCrossRefGoogle Scholar
  124. 124.
    Marin-Padilla, M. Origin, nature and significance of the “embryoids” of human teratomas. Virchow’s Arch. Pathol. Anat. 340: 105, 1965.Google Scholar
  125. 125.
    Marrubini, G. Primary chorionepithelioma of the ovary. Report of two cases. Acta Obstet. Gynecol. Scand. 28: 251, 1949.CrossRefGoogle Scholar
  126. 126.
    Masson, P.: Seminomes ovariennes. Bull. Soc. Anat. (Paris) 87: 402, 1912.Google Scholar
  127. 127.
    Masson, P. Epitheliomas pfliigeriens, in Diagnostics de laboratoire. Les tumeurs. Paris, Maloine, 1923.Google Scholar
  128. 128.
    Mathieu, J., and Planchu, M. Le prognostic et le traitement du seminome de l’ovaire. Les oestrogenes out-ils place dans le traitement du seminome en general ? Lyon Chir. 45: 76, 1950.PubMedGoogle Scholar
  129. 129.
    Matz, M. H. Benign cystic teratomas of the ovary. Obstet. Gynecol. Surv. 16: 591, 1961.CrossRefGoogle Scholar
  130. 130.
    Melicow, M. M., and Uson, A. C. Dysgenetic gonadomas and other gonadal neoplasms in intersex. Cancer 12: 552, 1959.PubMedCrossRefGoogle Scholar
  131. 131.
    Meyer, R. The pathology of some special ovarian tumors and their relation to sex characteristics. Am. J. Obstet. Gynecol. 22: 697, 1931.Google Scholar
  132. 132.
    Moertel, C. G., Beahrs, O. H., Woolner, L. B., and Tyce, G. M. “Malignant carcinoid syndrome” associated with noncarcinoid tumors. New Engl. J. Med. 273: 244, 1965.Google Scholar
  133. 133.
    Mueller, C. W., Topkins, P., and Lapp, W. A. Dysgerminoma of the ovary. An analysis of 427 cases. Am. J. Obstet. Gynecol. 60: 153, 1950.Google Scholar
  134. 134.
    Neigus, I. Ovarian dysgerminoma with chorio-nepithelioma. Am. J. Obstet. Gynecol. 64: 422, 1952.Google Scholar
  135. 135.
    Neubecker, R. D., and Breen, J. L. Embryonal carcinoma of the ovary. Cancer 15: 546, 1962.PubMedCrossRefGoogle Scholar
  136. 136.
    Nieminen, I., Von Numers, C., and Widholm, O. Struma ovarii. Acta Obstet. Gynecol. Scand. 42: 399, 1964.CrossRefGoogle Scholar
  137. 137.
    Norris, H. J., and Jensen, R. D. Relative frequency of ovarian neoplasms in children and adolescents. Cancer 30: 713, 1972.PubMedCrossRefGoogle Scholar
  138. 138.
    Novak, E. Gynecologic and Obstetric Pathology, 3rd ed. Philadelphia, W. B. Saunders, 1952.Google Scholar
  139. 139.
    Novak, E., and Gray, L. A. Dysgerminoma of the ovary. Am. J. Obstet. Gynecol. 35: 925, 1938.Google Scholar
  140. 140.
    Novak, E., Woodruff, J. D., and Novak, E. R. Probable mesonephric origin of certain female genital tumors. Am. J. Ob-stet. Gynecol. 68: 1224, 1954.Google Scholar
  141. 141.
    Novak, E. R. Solid teratoma of the ovary, with report of five cases. Am. J. Obstet. Gynecol. 56: 300, 1948.PubMedGoogle Scholar
  142. 142.
    Novak, E. R., and Woodruff, J. D. In Novak, E. R., ed. Gynecologic and Obstetric Pathology, 6th ed. Philadelphia, W. B. Saunders, 1967, p. 367.Google Scholar
  143. 143.
    Nystrom, C. Dysgerminoma of the ovary. Acta Obstet. Gynecol. Scand. 35: 385, 1956.CrossRefGoogle Scholar
  144. 144.
    Oliver, H. M., and Home, E. O. Primary teratomatous chorionepithelioma of the ovary. Report of a case. New Engl. J. Med. 239: 14, 1948.Google Scholar
  145. 145.
    Overbeck, L., and Philipp, E. Die Ultrastruktur des Disgerminoms im Over. Zugleich ein Beitrag zur Histogenese des Tumors. Z. Geburtschilfe Gynaekol. 170: 125, 1969.Google Scholar
  146. 146.
    Pantoja, E., Noy, M. A., Axtmayer, R. W., Colon, F. E., and Pelegrina, I. Ovarian dermoids and their complications. Comprehensive historical review. Obstet. Gynecol. Surv. 30: 1, 1975.PubMedCrossRefGoogle Scholar
  147. 147.
    Pantoja, E., Rodriguez-Ibanez, I., Axtmayer, R. W., Noy, M. A., and Pelegrina, I. Complications of dermoid tumors of the ovary. Obstet. Gynecol. 45: 89, 1975.Google Scholar
  148. 148.
    Park, I. J., Pyeatte, J. C., Jones, H. W., and Woodruff, J. D. Gonadoblastoma in a true hermaphrodite with 46XY genotype. Obstet. Gynecol. 40: 466, 1972.Google Scholar
  149. 149.
    Patel, S. K., and Prentice, S. A. Gonadoblastoma-distinctive ovarian tumor. Arch. Pathol. 94: 165, 1972.Google Scholar
  150. 150.
    Pedowitz, P., Felmus, L. B., and Grayzel, D. M. Dysgerminoma of the ovary. Prognosis and treatment. Am. J. Obstet. Gynecol. 70: 1284, 1955.PubMedGoogle Scholar
  151. 151.
    Peterson, W. F. Solid histologically benign teratomas of the ovary. A report of four cases and review of the literature. Am. J. Obstet. Gynecol. 72: 1094, 1956.Google Scholar
  152. 152.
    Peterson, W. F. Malignant degeneration of benign cystic teratomas of the ovary; a collective review of the literature. Ob-stet. Gynecol. Surv. 12: 793, 1957.Google Scholar
  153. 153.
    Peterson, W. F., Prevost, E. C., Edmunds, F. T., Huntley, J. M. Jr., and Morris, F. K. Benign cystic teratomas of the ovary. A clinico-statistical study of 1007 cases with review of the literature. Am. J. Obstet. Gynecol. 70: 368, 1955.Google Scholar
  154. 154.
    Peyron, A. Faits nouveaux relatifs à l’origine et à l’histogenese des embryomes. Bull. Ass. Franc. Cancer 28: 658, 1939.Google Scholar
  155. 155.
    Pierce, G. B. Jr. Ultrastructure of human testicular tumors. Cancer 19: 1963, 1966.PubMedCrossRefGoogle Scholar
  156. 156.
    Pierce, G. B. Jr., Bullock, W. K., and Huntington, R. W. Jr. Yolk sac tumors of the testis. Cancer 25: 644, 1970.PubMedCrossRefGoogle Scholar
  157. 157.
    Pierce, G. B. Jr., and Dixon, F. J. Testicular teratomas. 1. Demonstration of teratogenesis by metamorphosis of multipotential cells. Cancer 12: 573, 1959.PubMedCrossRefGoogle Scholar
  158. 158.
    Pierce, G. B. Jr., and Dixon, F. J. Testicular teratomas. 2. Teratocarcinoma as ascitic tumor. Cancer 12: 584, 1959.PubMedCrossRefGoogle Scholar
  159. 159.
    Pierce, G. B. Jr., and Midgley, A. R. The origin and function of human syncytiotrophoblastic giant cells. Am. J. Pathol. 43: 153, 1963.PubMedGoogle Scholar
  160. 160.
    Pierce, G. B. Jr., Midgley, A. R., and Beals, T. F. An ultra-structural study of differentiation and maturation of trophoblast of the monkey. Lab. Invest. 13: 451, 1962.Google Scholar
  161. 161.
    Pierce, G. B. Jr., Midgley, A. R., Sri Ram, J., and Feldman, J. D. Parietal yolk sac carcinoma. Clue to the histogenesis of Reichert’s membrane of the mouse embryo. Am. J. Pathol. 41: 549, 1964.Google Scholar
  162. 162.
    Pierce, G. B. Jr., and Verney, E. L. An in vitro and in vivo study of differentiation in teratocarcinomas. Cancer 14: 1017, 1961.PubMedCrossRefGoogle Scholar
  163. 163.
    Plaut, A. Ovarian struma: A morphologic, pharmacologic, and biologic examination. Am. J. Obstet. Gynecol. 25: 351, 1933.Google Scholar
  164. 164.
    Qizilbash, A. H., Trebilcock, R. G., Patterson, M. C., and Lamont, K. G. Functioning primary carcinoid tumor of the ovary. A light and electronmicroscopic study with review of the literature. Am. J. Clin. Pathol. 62: 629, 1974.PubMedGoogle Scholar
  165. 165.
    Ramsey, H. J. Ultrastructure of a pineal tumor. Cancer 18: 1014, 1965.PubMedCrossRefGoogle Scholar
  166. 166.
    Rao, N. R., Veliath, G. D., and Srinivasan, M. An unusual case of sacrococcygeal mesonephroma (Schiller). Cancer 17: 1604, 1964.PubMedCrossRefGoogle Scholar
  167. 167.
    Rashad, M. H., Fathalla, M. F., and Kerr, M. C. Sex chromatin and chromosome analysis in ovarian teratomas. Am. J. Obstet. Gynecol. 96: 461, 1966.PubMedGoogle Scholar
  168. 168.
    Robboy, S. J., and Scully, R. E. Ovarian teratoma with glial implants on the peritoneum. An analysis of 12 cases. Hum. Pathol. 1: 643, 1970.Google Scholar
  169. 169.
    Robboy, S. J., Scully, R. E., and Norris, H. J. Carcinoid metastatic to the ovary. A clinicopathologic analysis of 35 cases. Cancer 33: 798, 1974.PubMedCrossRefGoogle Scholar
  170. 170.
    Rose, L. I., Underwood, R. H., Williams, G. H., and Pincus, G. S. Pure gonadal dysgenesis. Studies of in vitro androgen metabolism. Am. J. Med. 57: 957, 1974.PubMedCrossRefGoogle Scholar
  171. 171.
    Sailer, S.: Ovarian dysgerminoma. Am. J. Cancer 38: 473, 1940.Google Scholar
  172. 172.
    Sailer, S. Struma ovarii. Am. J. Clin. Pathol. 13: 271, 1943.Google Scholar
  173. 173.
    Salet, J., de Gennes, L. J., de Grouchy, J., Musset, R., Pelissier, C., Yaneva, H., Sebaoun, M., and Netter, A. A propos d’un cas de gonadoblastome 46XX. Ann. Endocrinol. (Paris) 31: 927, 1970.Google Scholar
  174. 174.
    Santesson, L. Clinical and pathological survey of ovarian tumours treated at the Radiumhemmet. 1. Dysgerminoma. Acta Radiol. (Stockholm) 28: 643, 1947.Google Scholar
  175. 175.
    Santesson, L., and Marrubini, G. Clinical and pathological survey of ovarian embryonal carcinomas, including so-called “mesonephromas” (Schiller) or “mesoblastomas” (Teilum) treated at the Radiumhemmet. Acta Obstet. Gynecol. Scand. 36: 399, 1957.Google Scholar
  176. 176.
    Saunders, A. M., and Hertzman, V. O. Malignant carcinoid teratoma of the ovary. Can. Med. Ass. J. 83: 602, 1960.Google Scholar
  177. 177.
    Schellhas, H. F. Malignant potential of the dysgenetic gonad. Part 1. Obstet. Gynecol. 44: 298, 1974.Google Scholar
  178. 178.
    Schellhas, H. F. Malignant potential of the dysgenetic gonad. Part 2. Obstet. Gynecol. 44: 455, 1974.Google Scholar
  179. 179.
    Schellhas, H. F., Trujillo, J. M., Rutledge, F. N., and Cork, A. Germ cell tumors associated with XY gonadal dysgenesis. Am. J. Obstet. Gynecol. 109: 1197, 1971.Google Scholar
  180. 180.
    Schiller, W. Mesonephroma ovarii. Am. J. Cancer 35: 1, 1939.Google Scholar
  181. 181.
    Schiller, W. Histogenesis of ovarian mesonephroma. Arch. Pathol. 33: 443, 1942.Google Scholar
  182. 182.
    Schmitz, E. F. Malignant endothelioma of perithelioma type in the ovary. Am. J. Obstet. Gynecol. 9: 247, 1925.Google Scholar
  183. 183.
    Scully, R. E. Gonadoblastoma. A gonadal tumor related to dysgerminoma (seminoma) and capable of sex hormone production. Cancer 6: 455, 1953.PubMedCrossRefGoogle Scholar
  184. 184.
    Scully, R. E. Germ cell tumors of the ovary and Fallopian tube. In Meigs, J. V., and Sturgis, S. H., eds. Progress in Gynecology. New York, Grune and Stratton, 1963, Vol. 4, pp. 335–347.Google Scholar
  185. 185.
    Scully, R. E. Germ cell tumors of the ovary. In Sturgis, S. H., and Taymor, M. L., eds. Progress in Gynecology. New York, Grune and Stratton, 1970, Vol. 5, pp. 329–348.Google Scholar
  186. 186.
    Scully, R. E. Recent progress in ovarian cancer. Hum. Pathol. 1: 73, 1970.Google Scholar
  187. 187.
    Scully, R. E. Gonadoblastoma. Cancer 25: 1340, 1970.CrossRefGoogle Scholar
  188. 188.
    Scully, R. E. Sex cord tumor with annular tubules. A distinctive ovarian tumor of the Peutz-Jeghers syndrome. Cancer 25: 1107, 1970.PubMedCrossRefGoogle Scholar
  189. 189.
    Seegar, G. E. Ovarian dysgerminomas. Arch. Surg. 37: 697, 1938.Google Scholar
  190. 190.
    Serov, S. F., Scully, R. E., and Sobin, L. H. Histological typing of ovarian tumors. International histological classification of tumors, No. 9. Geneva, World Health Organization, 1973.Google Scholar
  191. 191.
    Sjovall, A. Disgerminome des Ovariums. Acta Obstet. Gynecol. Scand. 23: 585, 1943.CrossRefGoogle Scholar
  192. 192.
    Simard, L. C. Polyembryonic embryoma of the ovary of parthenogenetic origin. Cancer 10: 215, 1957.PubMedCrossRefGoogle Scholar
  193. 193.
    Smith, F. G. Pathology and physiology of struma ovarii. Arch. Surg. 53: 603, 1946.Google Scholar
  194. 194.
    Smith, J. B., and O’Neill, R. T. Alpha-fetoprotein. Occurrence in germinal cell and liver malignancies. Am. J. Med. 51: 767, 1971.PubMedCrossRefGoogle Scholar
  195. 195.
    Smith, J. P., Rutledge, F. N., and Sutow, W. W. Malignant gynecologic tumors in children. Current approaches to treatment. Am. J. Obstet. Gynecol. 116: 261, 1963.Google Scholar
  196. 196.
    Solomon, J., Steinfeld, J. L., and Bateman, J. R. Chemotherapy of germinal tumors. Cancer 26: 747, 1967.CrossRefGoogle Scholar
  197. 197.
    Sternberg, W. H., Barclay, D. L., and Kloepfer, H. W. Familial XY gonadal dysgenesis. New Engl. J. Med. 278: 695, 1968.PubMedCrossRefGoogle Scholar
  198. 198.
    Stevens, L. C. Embryology of testicular teratomas in strain 129 mice. J. Natl. Cancer Inst. 23: 1249, 1959.Google Scholar
  199. 199.
    Stevens, L. C. Embryonic potency of embryoid bodies derived from a transplantable testicular teratoma of the mouse. Develop. Biol. 2: 285, 1960.Google Scholar
  200. 200.
    Stevens, L. C. The biology of teratomas including evidence indicating their origin from primordial germ cells. Ann. Biol. 1: 585, 1962.Google Scholar
  201. 201.
    Strauss, A. F., and Gates, H. S. Giant sebaceous gland tumor of the ovary. Am. J. Clin. Pathol. 41: 78, 1964.Google Scholar
  202. 202.
    Talerman, A. Gonadoblastoma and dysgerminoma in two siblings with dysgenetic gonads. Obstet. Gynecol. 38: 416, 1971.Google Scholar
  203. 203.
    Talerman, A. A distinctive gonadal neoplasm related to gonadoblastoma. Cancer 30: 1219, 1972.PubMedCrossRefGoogle Scholar
  204. 204.
    Talerman, A. A mixed germ cell-sex cord stroma tumor in a normal female infant. Obstet. Gynecol. 40: 473, 1972.Google Scholar
  205. 205.
    Talerman, A. Gonadoblastoma associated with embryonal carcinoma. Obstet. Gynecol. 43: 138, 1974.Google Scholar
  206. 206.
    Talerman, A. The incidence of yolk sac tumor (endodermal sinus tumor) elements in germ cell tumors of the testis in adults. Cancer 36: 211, 1975.PubMedCrossRefGoogle Scholar
  207. 207.
    Talerman, A., and Delemarre, J. F. M. Gonadoblastoma associated with embryonal carcinoma in an anatomically normal male. J. Urol. 113: 355, 1975.Google Scholar
  208. 208.
    Talerman, A., and Haije, W. G. Alpha-fetoprotein and germ cell tumors: A possible role of yolk sac tumor in production of alpha-fetoprotein. Cancer 34: 1722, 1974.PubMedCrossRefGoogle Scholar
  209. 209.
    Talerman, A., Huyzinga, W. T., and Kuipers, T. Dysgerminoma. Clinicopathologic study of 22 cases. Obstet. Gynecol. 41: 137, 1973.Google Scholar
  210. 210.
    Taylor, C. W. Mullerian mixed tumor. Acta Pathol. Microbiol. Scand., 80A Suppl., 233: 48, 1972.Google Scholar
  211. 211.
    Teilmann, I., Kassis, H., and Pietra, G. Primary germ cell tumour of the anterior mediastinum with features of endodermal sinus tumour (mesoblastoma vitellinum). Acta Pathol. Microbiol. Scand. 70: 267, 1967.CrossRefGoogle Scholar
  212. 212.
    Teilum, G.: Homologous tumours in ovary and testis; contribution to classification of gonadal tumours. Acta Obstet. Gynecol. Scand. 24: 480, 1944.Google Scholar
  213. 213.
    Teilum, G. Gonocytoma; homologous ovarian and testicular tumours; 1; with discussion of “mesonephroma ovarii” (Schiller: Amer. J. Cancer 1939). Acta Pathol. Microbiol. Scand. 23: 242, 1946.CrossRefGoogle Scholar
  214. 214.
    Teilum, G. “Mesonephroma ovarii” (Schiller) extra-embryonic mesoblastoma of germ cell origin in ovary and testis. Acta Pathol. Microbiol. Scand. 27: 249, 1950.CrossRefGoogle Scholar
  215. 215.
    Teilum, G. Classification of ovarian tumours. Acta Obstet. Gynecol. Scand. 31: 292, 1952.CrossRefGoogle Scholar
  216. 216.
    Teilum, G. Endodermal sinus tumors of the ovary and testis. Comparative morphogenesis of the so-called mesonephroma ovarii (Schiller) and extraembryonic (Yolk sac-allantoic) structures of the rat’s placenta. Cancer 12: 1092, 1959.PubMedCrossRefGoogle Scholar
  217. 217.
    Teilum, G. Classification of endodermal sinus tumour (mesoblastoma vitellinum) and so-called “embryonal carcinoma” of the ovary. Acta Pathol. Microbiol. Scand. 64: 407, 1965.Google Scholar
  218. 218.
    Teilum, G. Tumours of germinal origin, in Gentil, F., and Junqueira, A. C., eds.: Ovarian Cancer, U.I.C.C. Monograph Series. Berlin, Heidelberg, New York, Springer-Verlag, 1968, Vol. 11, pp. 58–73.Google Scholar
  219. 219.
    Teilum, G. Special Tumors of the Ovary and Testis. Comparative histology and identification. Copenhagen, Munksgaard Co., 1971.Google Scholar
  220. 220.
    Teilum, G., Albrechtsen, R., and Norgaard-Pedersen, B. Immunofluorescent localization of alpha-fetoprotein synthesis in endodermal sinus tumor (yolk sac tumor). Acta Pathol. Microbiol. Scand. 82A: 586, 1974.Google Scholar
  221. 221.
    Teilum, G., Albrechtsen, R., and Norgaard-Pedersen, B. The histogenetic-embryologic basis for reappearance of alphafetoprotein in endodermal sinus tumors and teratomas. Acta Pathol. Microbiol. Scand. 83A: 80, 1975.Google Scholar
  222. 222.
    Teter, J. A new concept of classification of gonadal tumors arising from germ cell (gonocytoma) and their histogenesis. Gynaecologia (Basel) 150: 84, 1960.Google Scholar
  223. 223.
    Teter, J. A mixed form of feminizing germ cell tumor (gonocytoma II). Am. J. Obstet. Gynecol. 84: 722, 1962.PubMedGoogle Scholar
  224. 224.
    Teter, J. Prognosis, malignancy and curability of the germ cell tumor occurring in dysgenetic gonads. Am. J. Obstet. Gynecol. 108: 894, 1970.PubMedGoogle Scholar
  225. 225.
    Teter, J. and Boczkowski, K. Occurrence of tumors in dysgenetic gonads. Cancer 20: 1301, 1967.PubMedCrossRefGoogle Scholar
  226. 226.
    Theiss, E. A., Ashley, D. J. B., and Mostofi, F. K. Nuclear sex of testicular tumors and some related ovarian and extra-gonadal neoplasms. Cancer 13: 323, 1959.CrossRefGoogle Scholar
  227. 227.
    Thoeny, R. H., Dockerty, M. B., Hunt, A. B., and Childs, D. S. Jr. Study of ovarian dysgerminoma with emphasis on the role of radiation therapy. Surg. Gynecol. Obstet. 113: 692, 1961.Google Scholar
  228. 228.
    Thurlbeck, W. M., and Scully, R. E. Solid teratoma of the ovary. Cancer 13: 804, 1960.PubMedCrossRefGoogle Scholar
  229. 229.
    Toker, C. Ovarian carcinoid. A light and electron microscopic study. Am. J. Obstet. Gynecol. 103: 1019, 1969.PubMedGoogle Scholar
  230. 230.
    Turner, H. B., Douglas, W. M., and Cladding, T C Choriocarcinoma of the ovary. Obstet. Gynecol. 24: 918, 1964.Google Scholar
  231. 231.
    Uzisima, H. Ovarian dysgerminoma associated with virilization. Report of a case. Cancer 9: 736, 1956.CrossRefGoogle Scholar
  232. 232.
    Vawter, G. F. Carcinoma of the vagina in infancy. Cancer 18: 1479, 1965.PubMedCrossRefGoogle Scholar
  233. 233.
    Wheatley, V. R. Further observations on the nature of the dermoid cyst fat. J. Invest. Dermatol. 29: 445, 1957.Google Scholar
  234. 234.
    Whelton, J. A., and Fallon, R. J. Successful pregnancy after surgery and supervoltage therapy for metastatic dysgerminoma. New Eng. J. Med. 271: 145, 1964.Google Scholar
  235. 235.
    Wider, J. A., Marshall, J. R., Bardin, C. W., Lipsett, M. B., and Rose, G. T. Sustained remissions after chemotherapy for primary ovarian cancers containing choriocarcinoma. New Engl. J. Med. 280: 1439, 1969.PubMedCrossRefGoogle Scholar
  236. 236.
    Wider, J. A., and O’Leary, J. A. Dysgerminoma: a clinical review. Obstet. Gynecol. 31: 560, 1968.PubMedGoogle Scholar
  237. 237.
    Wieland, R. G., Ekstrom, B., and Vorijs, N. C19O2 Steroid secretion by dysgenetic gonads. Obstet. Gynecol. 32: 643, 1968.Google Scholar
  238. 238.
    Wilkinson, E. J., Friedrich, E. G., and Hosty, T. A. Alphafetoprotein and endodermal sinus tumor of the ovary. Am. J. Obstet. Gynecol. 116: 711, 1973.PubMedGoogle Scholar
  239. 239.
    Williams, E. D. Histogenesis of medullary carcinoma of the thyroid. J. Clin. Pathol. 19: 114, 1966.CrossRefGoogle Scholar
  240. 240.
    Williams, E. D., and Sandler, M. Classification of carcinoid by embryologic grouping. Lancet 1: 238, 1963.PubMedCrossRefGoogle Scholar
  241. 241.
    Willis, R. A. The Borderland of Embryology and Pathology. London, Butterworth, 1958.Google Scholar
  242. 242.
    Willis, R. A. Pathology of Tumours, 4th ed. London, Butterworth, 1967.Google Scholar
  243. 243.
    Wisniewski, M., and Deppisch, L. M. Solid teratomas of the ovary. Cancer 32: 440, 1973.PubMedCrossRefGoogle Scholar
  244. 244.
    Witschi, E. Migration of the germ cells of human embryos from the yolk sac to the primitive gonadal folds. Contrib. Embryo]. 32: 69, 1948.Google Scholar
  245. 245.
    Woodruff, J. D., and Markley, R. L. Struma ovarii. Demonstration of both pathologic change and physiologic activity; report of four cases. Obstet. Gynecol. 9: 707, 1957.PubMedCrossRefGoogle Scholar
  246. 246.
    Woodruff, J. D., Protos, P., and Peterson, W. F. Ovarian teratomas. Relationship of histologic and ontogenic factors to prognosis. Am. J. Obstet. Gynecol. 102: 702, 1968.PubMedGoogle Scholar
  247. 247.
    Woodruff, J. D., Rauh, J. T., and Markley, R. L. Ovarian struma. Obstet. Gynecol. 27: 194, 1966.PubMedGoogle Scholar
  248. 248.
    Wurster, K., Hedinger, C., and Meienberg, O. Orchioblastomatous foci in testicular teratoma of adults. Virchow’s Arch. Pathol. Anat. 357: 231, 1972.CrossRefGoogle Scholar

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© Springer Science+Business Media New York 1977

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  • A. Talerman
  • M. R. C. Path

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