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E7 Protein

  • Massimo Tommasino
  • Pidder Jansen-Dürr

Abstract

The first evidence for an involvement of the E7 protein in malignant transformation came from studies on HPV-infected cells. In several cervical carcinoma-derived cell lines, such as SiHa, CaSki and HeLa, the HPV DNA is integrated in the cellular genome as single or multiple copies. This viral DNA integration results in the disruption of several viral genes with consistent preservation of only the early E6 and E7 genes (for more detail see chapter 2). The involvement of the E7 protein in immortalization and transformation of the host cell was confirmed by a number of in vitro assays and by transgenic mouse models. Biochemical studies have provided further evidence that the E7 protein is directly involved in the induction of immortalization and malignant transformation of the host cells. E7 proteins from the “high risk” HPV types have the ability to interact with and alter the function of a number of cellular proteins which play a key role in controlling the proliferative program of the cell.

Keywords

Pocket Protein Upstream Binding Factor CXXC Motif 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • Massimo Tommasino
  • Pidder Jansen-Dürr

There are no affiliations available

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