NIRS Mediated CBF Assessment: Validating the Indocyanine Green Bolus Transit Detection by Comparison with Coloured Microsphere Flowmetry

  • Geofrey De Visscher
  • Veerle Leunens
  • Marcel Borgers
  • Robert S. Reneman
  • Willem Flameng
  • Koen van Rossem
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 540)


The aim of this study was to validate the blood flow index (BFI), derived from the transit of an indocyanine green bolus through the brain as monitored with near infra-red spectroscopy, for the measurement of cerebral blood flow (CBF) in rats..The validation was performed by comparing the weight corrected BFI (BFIw) to paired flow measurements obtained be coloured microsphere flowmetry under normal and altered CBF. We conclude that the BFIw is an accurate predictor of global CBF as measured with coloured microspheres.


Cerebral Blood Flow Closed Head Injury Bolus Transit Global Cerebral Blood Flow Blood Flow Index 


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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Geofrey De Visscher
    • 1
    • 2
  • Veerle Leunens
    • 2
  • Marcel Borgers
    • 1
  • Robert S. Reneman
    • 1
  • Willem Flameng
    • 2
  • Koen van Rossem
    • 3
  1. 1.Department of Molecular Cell Biology, CARIMUniversity of MaastrichtThe Netherlands
  2. 2.CEHACatholic University of LeuvenLeuvenBelgium
  3. 3.Center of Excellence for Cardiovascular Safety ResearchJohnson & Johnson Pharmaceutical Research & DevelopmentBeerseBelgium

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