NIRS Mediated CBF Assessment: Validating the Indocyanine Green Bolus Transit Detection by Comparison with Coloured Microsphere Flowmetry
The aim of this study was to validate the blood flow index (BFI), derived from the transit of an indocyanine green bolus through the brain as monitored with near infra-red spectroscopy, for the measurement of cerebral blood flow (CBF) in rats..The validation was performed by comparing the weight corrected BFI (BFIw) to paired flow measurements obtained be coloured microsphere flowmetry under normal and altered CBF. We conclude that the BFIw is an accurate predictor of global CBF as measured with coloured microspheres.
KeywordsCerebral Blood Flow Closed Head Injury Bolus Transit Global Cerebral Blood Flow Blood Flow Index
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