Modeling of Oxygen Diffusion and Metabolism from Capillary to Muscle
In the bioengineering and sports training field, there are interests in obtaining information on oxygen transport and metabolism during muscle exercise. The goal of our study was to develop a time-dependent model which can simulate the changes in oxygen diffusion and metabolism in muscle tissue, especially from capillary to mitochondria. We postulate that oxygen diffuses into the tissue at a rate proportional to the oxygen concentration in plasma when applied to a steady state condition. As we know, any build up of oxygen in the tissue is directly related to oxygen leaving the capillary into the tissue and the consumption of oxygen by the mitochondria, or the metabolic demand. We designed a model which consisted of four compartments: (1) capillary; (2) interstitial space between capillary and myofibril tissue cell; (3) parenchymal cell through myofibril to mitochondria in muscle tissue; (4) at mitochondria. Oxygen comes from arteriole to capillary, then diffuses to mitochondria through interstitial space and myofibril. Oxygen is reduced to water in mitochondria, and ATP is generated through proton transport. Our model simulates the measured oxygen uptake during rest and muscle exercise as the input oxygen uptake represented as H2O formation.
KeywordsOxygen Concentration Oxygen Diffusion Interstitial Space Oxygen Transport Differential Equation Model
Unable to display preview. Download preview PDF.
- 1.George A. Brooks, Thomas D. Fahey and Timothy P.White, Exercise Physiology: Human Bioenergetics and Its Applications,2nd ed., pp. 579-581.Google Scholar
- 2.Chandan K. Sen, Lester Packer and Osmo O.P. Hanninen, Handbook of Oxidants and Antioxidants in Exercise, Elsevier Science B.V., 2000.Google Scholar
- 3.Modeling and Imaging, the National Simulation Resource in Circulatory Mass-Transport & Exchange. NSR Simulation Analysis Workshop, University of Washington. Sep. 2001.Google Scholar
- 4.Bruce Alberts, Dennis Bray, Julian Lewis, Martin Raff, Keith Robert, James D. Watson, Molecular Biology of the Cell, 3rd ed, 1994, pp. 653 - 684.Google Scholar