Abstract
In the study of peripheral occlusive disease (e.g. progressive ischaemic syndrome), many parameters have been investigated using different methods and techniques: including hemorheology, microcirculatory blood flow, tissue oxygenation, microvasculature red blood cell (RBC) perfusion, and RBC deformability and aggregability in vitro with the laser assisted optical rotational red blood cells analyzer (LORCA)1−3. In addition, to explain some biochemical aspects we detected the intra-RBC cytosolic calcium (Ca++) level4,5. The oxygen carrying capacity of microcirculatory blood has also been studied, as transcutaneous oxygen partial pressure (TcpO2)6, oxyhemoglobin saturation percentage (% sat HbO2) using standard instruments and our prototype Oxyraf7,8, as well as total oxygen concentration9. We were particularly interested in the microcirculation in peripheral occlusive arterial disease (POAD) focusing on in vivo studies with capillaroscopy of morphology in relation to assessment of tissue oxygenation. Therefore, in the present study we investigated whether these two methodologies could be combined to evaluate microvasculature capillaries, especially in arterial vasculopathy, to define microvasculature perfusion.
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Cicco, G., Placanica, G., Memeo, V., Lugarà, P.M., Nitti, L., Migliau, G. (2003). Microcirculation Assessment in Vasculopathies. In: Thorniley, M., Harrison, D.K., James, P.E. (eds) Oxygen Transport to Tissue XXV. Advances in Experimental Medicine and Biology, vol 540. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-6125-2_38
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DOI: https://doi.org/10.1007/978-1-4757-6125-2_38
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