Influence of Neuronally Derived Nitric Oxide on Blood Oxygenation and Cerebral pO2 in a Mouse Model Measured by EPR Spectrometry
Nitric oxide (NO·) is widely accepted as a key component in the maintenance of resting cerebral blood flow (CBF). The complex interaction between NO· and other regulatory mediators such as neural activity, pH and arterial pCO2 determines the tone of cerebral blood vessels and thus oxygen delivery through blood flow 1−3.
KeywordsNitric Oxide Cerebral Blood Flow Cerebral Blood Flow Response Neuron Ally Oximetry Measurement
Unable to display preview. Download preview PDF.
- 7.Kumura, E. et al., “Generation of nitric oxide and superoxide during reperfusion after focal cerebral ischemia in rats,” Am.iPhysiol270 (3 Pt 1 ): C748 - C752 (1996).Google Scholar
- 11.Santizo, R., V. L. Baughman, and D. A. Pelligrino, “Relative contributions from neuronal and endothelial nitric oxide synthases to regional cerebral blood flow changes during forebrain ischemia in rats,” Neuroreport 11 (7): 1549–1553 (2000).Google Scholar
- 17.Cooper, G. R., K. Mialkowski, and D. J. Wolff, “Cellular and enzymatic studies ofN(omega)-propyl-larginine and S- ethyl-N-[4-(trifluoromethyl)phenyl]isothiourea as reversible, slowly dissociating inhibitors selective for the neuronal nitric oxide synthase isoform,” Arch.Biochem.Biophys. 375 (1): 183–194 (2000).PubMedCrossRefGoogle Scholar
- 18.Zhang, H. Q. et al., “Potent and selective inhibition of neuronal nitric oxide synthase by N omega-propyl-Larginine,” JMed.Chem. 40 (24): 3869–3870 (1997).Google Scholar
- 21.Campbell, D. and Spence, A.A. 1997, Norris and Campbell’s Anaesthetics, Resuscitation and Intensive Care, Churchill Livingstone, New York, pp. 83–123.Google Scholar
- 22.Miller, F.L. and Marshall, B.E, The Inhaled Anesthetics, in: Introduction to Anesthesia, Longnecker, D.E. and Murphy, F.L, ed., W.B. Saunders Company, Philadelphia, pp 84–90.Google Scholar
- 23.Rushman, G.B., Davies, N.J.H. and Cashman, J.N. Lee’s Synopsis of Anaesthesia,Butterworth-Heinemann, Oxford, pp 160–162Google Scholar