Steady-State MR Imaging with Mion for Quantification of Angiogenesis in Normal Brain and in Brain Tumors
Angiogenesis plays a role in the normal response of brain to low oxygen stress, as well as in many pathological conditions such as stroke and tumor growth. Angiogenesis, or the growth of new capillaries, will improve flow to ischemic areas of the brain, and the inhibition of angiogenesis is now a major target of new anti-cancer agents.
KeywordsCerebral Blood Flow Cerebral Blood Volume Chronic Hypoxia Hypobaric Hypoxia Custom Macro
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- 2.A. Gossmann, T.H. Helbich, N. Kuriyama, S. Ostrowitzki, T.P. Roberts, D.M. Shames, N. van Bruggen, M.F. Wendland, M.A. Israel, R.C. Brasch, Dynamic contrast-enhanced magnetic resonance imaging as a surrogate marker of tumor response to anti-angiogenic therapy in a xenograft model of glioblastoma multiforme, JMagn Reson Imag, 15 (3), 233–40 (2002).CrossRefGoogle Scholar
- 8.G.P. Paxinos, C. Watson. The rat brain in stereotaxic coordinates. London: Academic Press, 1986.Google Scholar
- 10.J.A. Boero, J. Ascher, A. Arregui, C. Rovainen, T.A. Woolsey, Increased brain capillaries in chronic hypoxia, JAppl Physiol, 86 (4), 1211–9 (1999).Google Scholar
- S.P. Lee, T.Q. Duong, G. Yang, C. Iadecola, S.G. Kim, Relative changes of cerebral arterial and venous blood volumes during increased cerebral blood flow: implications for BOLD fMRI, Magn. Reson. in Med.,45(5), 791–800 (2001).Google Scholar