Pulsed Photothermal Radiometry Studies in Tissue Optics

  • I. Alex Vitkin
  • Brian C. Wilson
  • R. R. Anderson
Part of the Lasers, Photonics, and Electro-Optics book series (LPEO)


The phenomenon of thermal radiative emission is the basis of a materials evaluation technique known as photothermal radiometry. This technique involves irradiation of the sample with monochromatic light which is absorbed, causing a temperature rise. The increase in the blackbody radiative emission due to this rise is recorded with an infrared detector that views the sample surface. The detected signal contains information about the optical and thermal properties of the sample. Previous studies have used either modulated or pulsed light excitation methods; in this chapter, we will examine the applicability of the latter approach, known as pulsed photothermal radiometry (PPTR), to the study of optical properties of tissue.


Diffusion Approximation Turbid Medium Optical Coefficient Tissue Optic Selective Photothermolysis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Leung WP, Tam AC. “Techniques of flash radiometry,” J. Appl. Phys. 56: 156–161 (1984).ADSCrossRefGoogle Scholar
  2. 2.
    Imhof RE, Birch DJS, Thornley FR, Gilchrist JR, Strivens TA. “Optothermal transient emission radiometry,” J. Phys. E: Sci. Instrum. 17: 521–525 (1984).ADSCrossRefGoogle Scholar
  3. 3.
    Born M, and Wolf E. Principles of Optics, Pergamon Press, New York, 1980.Google Scholar
  4. 4.
    Imhof RE, Birch DJS, Thornley FR, Gilchrist JR, Strivens TA. “Opto-thermal monitoring of paint degradation,” J. Phys. D: Appl. Phys. 18: 103–106 (1985).ADSCrossRefGoogle Scholar
  5. 5.
    Balageas DL, Krapez JC, Cielo P. “Pulsed photothermal modeling of layered materials,” J. Appl. Phys. 59: 348–357 (1986).ADSCrossRefGoogle Scholar
  6. 6.
    Leung WP, Tam AC. “Thermal diffusivity in thin films measured by single-ended pulsed-laser-induced thermal radiometry,” Optics Lett. 9: 93–95 (1984).ADSCrossRefGoogle Scholar
  7. 7.
    Leung WP, Tam AC. “Thermal conduction at a contact interface measured by pulsed photothermal radiometry,” J. Appl. Phys. 63: 4505–4510 (1988).ADSCrossRefGoogle Scholar
  8. 8.
    Long FH, Deutsch TF. “Pulsed photothermal radiometry of human artery,” IEEE J. Quantum Electron. 23: 1821–1826 (1987).ADSCrossRefGoogle Scholar
  9. 9.
    Long FH, Nishioka NS, Deutsch TF. “Measurement of the optical and thermal properties of biliary calculi using pulsed photothermal radiometry,” Lasers Surg. Med. 7: 461–466 (1987).CrossRefGoogle Scholar
  10. 10.
    Long FH, Anderson RR, Deutsch TF. “Pulsed photothermal radiometry for depth profiling of layered media,” Appl. Phys. Lett. 51: 2076–2078 (1987).ADSCrossRefGoogle Scholar
  11. 11.
    Anderson RR, Beck H, Bruggemann U, Farinelli W, Jacques S, Parrish JA. “Pulsed photothermal radiometry in turbid media: Internal reflection strongly influences optical dosimetry,” Appl. Opt 28: 2256–2262 (1989).ADSCrossRefGoogle Scholar
  12. 12.
    Prahl SA, Vitkin IA, Bruggemann U, Wilson BC, Anderson RR. “Determination of optical properties of turbid media using pulsed photothermal radiometry,” Phys. Med. Biol. 37: 1203–1217 (1992).CrossRefGoogle Scholar
  13. 13.
    Vitkin IA, Wilson BC, Kaplan RS, Anderson RR. “The feasibility of monitoring exogenous dye uptake in tissue in vivo using pulsed photothermal radiometry,” J. Photochem. Photobiol. B: Biol. 16: 235–239 (1992).CrossRefGoogle Scholar
  14. 14.
    Carslaw HS, Jaeger JC. Conduction of Heat in Solids, Claredon, Oxford, 1986.zbMATHGoogle Scholar
  15. 15.
    Arpaci VS. Conduction Heat Transfer, Addison-Wesley, Menlo Park, 1966.zbMATHGoogle Scholar
  16. 16.
    Brewster MQ. Thermal Radiative Transfer and Properties, McGraw-Hill, New York, 1992.Google Scholar
  17. 17.
    Patterson MS, Wilson BC, Wyman DR. “The propagation of optical radiation in tissue I: Models of radiation transport and their application,” Lasers Med. Sci. 6: 155–168 (1991).CrossRefGoogle Scholar
  18. 18.
    Duderstadt JJ, Hamilton LJ. Nuclear Reactor Analysis, Wiley, New York, 1976.Google Scholar
  19. 19.
    Ishumaru A. Wave Propagation and Scattering in Random Media, Vol. 1, Academic, New York, 1978.Google Scholar
  20. 20.
    Patterson MS, Wilson BC, Graff R. “In vivo tests of the concept of photodynamic threshold dose in normal rat liver photosensitized by aluminum chlorosulphonated phthalocyanine,” Photochem. Photobiol. 51: 343–349 (1990).CrossRefGoogle Scholar
  21. 21.
    Egan WG, Hilgeman TW. Optical Properties of Inhomogeneous Materials, Academic Press, New York, 1979.Google Scholar
  22. 22.
    Flock ST, Patterson MS, Wilson BC, Wyman DR. “Monte Carlo modeling of light propagation in highly scattering tissues, I: Model predictions and comparison with diffusion theory,” IEEE Trans. Biomed. Eng. 36: 1162–1168 (1989).CrossRefGoogle Scholar
  23. 23.
    Nordal P-E, Kanstad SO. “Visible-light spectroscopy by photothermal radiometry using an incoherent source,” Appl. Phys. Lett. 38: 486–488 (1981).ADSCrossRefGoogle Scholar
  24. 24.
    Bults G, Nordal P-E, Kanstad SO. “In vivo studies of gross photosynthesis in attached leaves by means of photothermal radiometry,” Biochim. Biophys. Acta 682: 234–237 (1982)CrossRefGoogle Scholar
  25. 25.
    Obremski SM, LaMuraglia GL, Bruggemann U, Anderson RR. “A comparison of thermal and optical techniques for describing light interaction with vascular grafts, sutures and thrombus,” Laser—Tissue Interactions II, SPIE 1427: 327–334 (1991).ADSCrossRefGoogle Scholar
  26. 26.
    Imhof RE, Whitters CJ, Birch DJS. “Opto-thermal in vivo monitoring of sunscreens on skin,” Phys. Med. Biol. 35: 95–102 (1990).CrossRefGoogle Scholar
  27. 27.
    Wilson BC. “Modeling and measurements of light propagation in tissue for diagnostic and therapeutic applications,” in Chester AN (ed.), Laser Systems for Photobiology and Photomedicine, Plenum Press, New York, 1991, pp. 13–27.CrossRefGoogle Scholar
  28. 28.
    Anderson RR, Parrish JA. “Selective photothermolysis: precise microsurgery by selective absorption of pulsed radiation,” Science 220: 524–527 (1983).ADSCrossRefGoogle Scholar
  29. 29.
    Croitoru N, Dror J, Gannot I. “Characterization of hollow fibers for the transmission of infrared radiation,” Appl. Opt. 29: 1805–1809 (1990).ADSCrossRefGoogle Scholar
  30. 30.
    Zur A, Katzir A. “Use of infrared fibers for low temperature radiometric measurements,” Appl. Phy.s. Len. 48: 499–502 (1986).ADSCrossRefGoogle Scholar
  31. 31.
    Drexhage MG. “Glass optical fibers enter the infrared,” Laser Focus World, 27: 149–153 (1991).Google Scholar

Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • I. Alex Vitkin
    • 1
  • Brian C. Wilson
    • 2
  • R. R. Anderson
    • 3
  1. 1.Department of Clinical PhysicsPrincess Margaret HospitalTorontoCanada
  2. 2.Department of Medical Biophysics, Ontario Cancer Institute; Ontario Laser and Lightwave Research CentreUniversity of TorontoTorontoCanada
  3. 3.Wellman Laboratories of Photomedicine, Massachusetts General HospitalHarvard Medical SchoolBostonUSA

Personalised recommendations