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In Vitro Studies of Oligodendroglial Lipid Metabolism

  • David Pleasure
  • Seung U. Kim
  • Donald H. Silberberg
Part of the Advances in Neurochemistry book series (ANCH, volume 5)

Abstract

The only known function of oligodendroglia at present is to myelinate axons in the CNS. Myelin is a lipid-rich oligodendroglial plasma-membrane derivative containing galactolipids, cholesterol, and phospholipids in a molar ratio of about 1:2:2. In vivo studies have established the normal sequences of oligodendroglial maturation and myelination and have identified diseases in which initial CNS myelination is not carried to completion, such as phenylketonuria (PKU) and Krabbe’s disease, or in which normally myelinated CNS becomes demyelinated, such as multiple sclerosis (MS). Identification of the special metabolic characteristics of oligodendroglia that facilitate and regulate myelin synthesis and myelin maintenance will lead to a better understanding of the pathogenesis of dysmyelinative and demyelinative diseases.

Keywords

Schwann Cell Myelin Basic Protein Experimental Allergic Encephalomyelitis Radioactive Precursor Myelin Lipid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • David Pleasure
    • 1
  • Seung U. Kim
    • 2
  • Donald H. Silberberg
    • 1
  1. 1.Children’s Hospital of Philadelphia and Departments of Neurology and PediatricsUniversity of PennsylvaniaPhiladelphiaUSA
  2. 2.Division of NeurologyUniversity of British ColumbiaVancouverCanada

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