Production and Application of Natural Stabilizing Compounds from Halotolerant Bacteria

  • Erwin A. Galinski
  • Thomas Sauer


Marine, halotolerant microorganisms have great potential for the production of organic osmolytes (compatible solutes), which typically attract water and stabilize biological structures in vivo and in vitro [Galinski, 1995]. In this study we describe the exploitation of the marine, extremely halotolerant Halomonas elongata for the semi-continuous production of the tetrahydropyrimidines ectoine and S,S-β-hydroxyectoine, both novel compatible solutes with applications as stress protectants for enzymes, DNA and whole cells [Lippert & Galinski, 1992; Lapidot et al., 1993; Louis et al., 1994] (Fig. 1).


Compatible Solute Organic Osmolytes Stress Protectant Guanidinium Chloride Hyperosmotic Shock 


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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Erwin A. Galinski
    • 1
  • Thomas Sauer
    • 2
  1. 1.Institute for BiochemistryWestfälische Wilhelms-UniversitätMünsterGermany
  2. 2.Preclinical Development VaccineChiron Behring GmbH & Co.MarburgGermany

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