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Neuroreceptors and Signal Transduction pp 343–357Cite as

Histaminergic Neuron System and its Function

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 236))

Abstract

Histamine as a neurotransmitter or a neuroregulator in the mammalian brain has been postulated on the basis of biochemical, pharmacological and neurophysiological studies (1–5). We have demonstrated the histaminergic neuron system in rat brain immunocytochemically (6,7) using antibody raised against histidine decarboxylase (HDC), the sole enzyme responsible for histamine synthesis, as a marker (8). Histamine neurons were found to be concentrated in the magnocellular nuclei in the posterior hypothalamic area of rat brain, such as the tuberai magnocellular nucleus, caudal magnocellular nucleus and postmammillary caudal magnocellular nucleus, while their fibers were found in many areas, such as the hypothalamus, cerebral cortex, olfactory nuclei, basal ganglia, hippocampus, septum, cerebellum, amygdaloid complex, nucleus of the diagonal band, bed nucleus of the stria terminalis, central gray, auditory system, medial vestibular nucleus, facial nucleus, dorsal parabrachial nucleus, and nucleus of the solitary tract (7). Similar results were observed using antibodies against histamine itself (9–11).

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Authors and Affiliations

  1. Department of Pharmacology II, Osaka University Medical School, Nakanoshima 4-3-57, Kita-ku, Osaka 530, Japan

    H. Wada. A. Yamatodani, N. Inagaki, N. Itowi, N. P. Wang & H. Fukui

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  1. H. Wada. A. Yamatodani
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  2. N. Inagaki
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  3. N. Itowi
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  4. N. P. Wang
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  5. H. Fukui
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Editor information

Editors and Affiliations

  1. Hiroshima University, Hiroshima, Japan

    Shozo Kito  & Tomio Segawa  & 

  2. Kyoto Prefectural University of Medicine, Kyoto, Japan

    Kinya Kuriyama

  3. Osaka University, Osaka, Japan

    Masaya Tohyama

  4. University of California, Los Angeles, Los Angeles, California, USA

    Richard W. Olsen

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© 1988 Springer Science+Business Media New York

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Yamatodani, H.W.A., Inagaki, N., Itowi, N., Wang, N.P., Fukui, H. (1988). Histaminergic Neuron System and its Function. In: Kito, S., Segawa, T., Kuriyama, K., Tohyama, M., Olsen, R.W. (eds) Neuroreceptors and Signal Transduction. Advances in Experimental Medicine and Biology, vol 236. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-5971-6_27

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  • DOI: https://doi.org/10.1007/978-1-4757-5971-6_27

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-5973-0

  • Online ISBN: 978-1-4757-5971-6

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